Pericytes are branched cells embedded within the basement membrane of capillaries and
post-capillary venules. They provide an incomplete investment to endothelial cells, thus …

Angiogenesis is defined as a new blood vessel sprouting from pre-existing vessels. This highly
regulated process take place through two non-exclusive events, the so-called endothelial …

Spontaneously arising tumor cells are not usually angiogenic at first. The phenotypic switch
to angiogenesis is usually accomplished by a substet that induces new capillaries that then …

Accumulation of mast cells (MCs) in tumours was described by Ehrlich in his doctoral thesis.
Since this early account, ample evidence has been provided highlighting participation of …

Nerve growth factor (NGF), a neurotrophin that plays a crucial role in promoting neurotrophic
and neurotropic effects in sympathetic neurons, has recently been identified as a novel …

Erythropoietin (Epo) is produced by the fetal liver and adult kidney and is an essential
stimulator of erythropoiesis. It has, however, been shown to modulate host cellular signal …

The nature of “soul” and the source of “psychic life”, the anatomical seat of cognitive, motor
and sensory functions, and the origin of neural diseases were broadly debated by ancient …

Although there has been considerable controversy since the observation by Ehrlich more than
100 years ago that the brain did not take up dyes from the vascular system, the concept of …

… They demonstrated that alternative activation of DCs by anti-inflammatory molecules, such
as calcitriol, prostaglandin E 2 (PGE 2 ) or IL-10 prompts them to secrete VEGF and inhibit …

Mast cells and eosinophils are the key cells in the early and late stages of allergic inflammation.
There is increasing evidence that angiogenesis plays an important role both in the …