AI in health and medicine
Artificial intelligence (AI) is poised to broadly reshape medicine, potentially improving the
experiences of both clinicians and patients. We discuss key findings from a 2-year weekly effort …
experiences of both clinicians and patients. We discuss key findings from a 2-year weekly effort …
If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans.
The notion that chronic stress fosters disease by activating the hypothalamic-pituitary-adrenocortical
(HPA) axis is featured prominently in many theories. The research linking chronic …
(HPA) axis is featured prominently in many theories. The research linking chronic …
[HTML][HTML] How mental health care should change as a consequence of the COVID-19 pandemic
The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns,
physical distancing, and other containment strategies; and the resulting economic …
physical distancing, and other containment strategies; and the resulting economic …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
…, RCK Chan, RYL Chen, EYH Chen, W Cheng… - The american journal of …, 2015 - cell.com
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
[HTML][HTML] Potently neutralizing and protective human antibodies against SARS-CoV-2
The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …
Evidence for Mixing
…, MG Wilson, LO Winstrom, E Chen, CH Cheng… - Physical review …, 2007 - APS
We present evidence for D 0− D 0 mixing in D 0→ K+ π− decays from 384 fb− 1 of e+ e−
colliding-beam data recorded near s= 10.6 GeV with the BABAR detector at the PEP-II storage …
colliding-beam data recorded near s= 10.6 GeV with the BABAR detector at the PEP-II storage …
Pembrolizumab as second-line therapy in patients with advanced hepatocellular carcinoma in KEYNOTE-240: a randomized, double-blind, phase III trial
…, E Chen, AB Siegel, AX Zhu, AL Cheng… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Pembrolizumab demonstrated antitumor activity and safety in the phase II
KEYNOTE-224 trial in previously treated patients with advanced hepatocellular carcinoma (HCC). …
KEYNOTE-224 trial in previously treated patients with advanced hepatocellular carcinoma (HCC). …
Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
…, W Henzel, T Le Bon, S Kathuria, E Chen - The EMBO …, 1986 - embopress.org
To identify structural characteristics of the closely related cell surface receptors for insulin
and IGF‐I that define their distinct physiological roles, we determined the complete primary …
and IGF‐I that define their distinct physiological roles, we determined the complete primary …
Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
…, L Coussens, S Munemitsu, TJ Dull, E Chen… - The EMBO …, 1987 - embopress.org
Structural features of v‐kit, the oncogene of HZ4 feline sarcoma virus, suggested that this gene
arose by transduction and truncation of cellular sequences. Complementary DNA cloning …
arose by transduction and truncation of cellular sequences. Complementary DNA cloning …
Observation of a Broad Structure in the Mass Spectrum around
…, P Spradlin, DC Williams, MG Wilson, J Albert, E Chen… - Physical review …, 2005 - APS
We study initial-state radiation events, e+ e−→ γ ISR π+ π− J/ψ, with data collected with the
BABAR detector. We observe an accumulation of events near 4.26 GeV/c 2 in the invariant-…
BABAR detector. We observe an accumulation of events near 4.26 GeV/c 2 in the invariant-…