CB2 receptors in the brain: role in central immune function

GA Cabral, ES Raborn, L Griffin… - British journal of …, 2008 - Wiley Online Library
Recently, it has been recognized that the cannabinoid receptor CB 2 may play a functionally
relevant role in the central nervous system (CNS). This role is mediated primarily through …

The Cannabinoid Delta-9-tetrahydrocannabinol Mediates Inhibition of Macrophage Chemotaxis to RANTES/CCL5: Linkage to the CB2 Receptor

ES Raborn, F Marciano-Cabral, NE Buckley… - Journal of NeuroImmune …, 2008 - Springer
The chemotactic response of murine peritoneal macrophages to RANTES/CCL5 was inhibited
significantly following pretreatment with delta-9-tetrahydrocannabinol (THC), the major …

Cannabinoids inhibit migration of microglial-like cells to the HIV protein Tat

D Fraga, ES Raborn, GA Ferreira, GA Cabral - Journal of Neuroimmune …, 2011 - Springer
Microglia are a population of macrophage-like cells in the central nervous system (CNS)
which, upon infection by the human immunodeficiency virus (HIV), secrete a plethora of …

Cannabinoid inhibition of macrophage migration to the trans-activating (Tat) protein of HIV-1 is linked to the CB2 cannabinoid receptor

ES Raborn, GA Cabral - Journal of Pharmacology and Experimental …, 2010 - ASPET
Macrophages and macrophage-like cells are important targets of HIV-1 infection at peripheral
sites and in the central nervous system. After infection, these cells secrete a plethora of …

Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins

ES Raborn, M Jamerson, F Marciano-Cabral… - Life sciences, 2014 - Elsevier
Aims The aim of this study was to assess the effect of select cannabinoids on human
immunodeficiency virus type 1 (HIV-1) transactivating (Tat) protein-enhanced monocyte-like cell …

Sex differences and drug dose influence the role of the α7 nicotinic acetylcholine receptor in the mouse dextran sodium sulfate-induced colitis model

…, HI Akbarali, PA Lichtman, ES Raborn… - Nicotine & Tobacco …, 2017 - academic.oup.com
Introduction: α7 nicotinic acetylcholine receptors (nAChRs) play an important role in vagus
nerve-based cholinergic anti-inflammatory effects. This study was designed to assess the role …

Acanthamoeba culbertsoni Elicits Soluble Factors That Exert Anti-Microglial Cell Activity

JL Harrison, GA Ferreira, ES Raborn… - Infection and …, 2010 - Am Soc Microbiol
Acanthamoeba culbertsoni is an opportunistic pathogen that causes granulomatous amoebic
encephalitis (GAE), a chronic and often fatal disease of the central nervous system (CNS). …

Delta-9-tetrahydrocannabinol, the major psychoactive component in marijuana, inhibits macrophage chemotaxis to Acanthamoeba.

F Marciano-Cabral, ES Raborn… - Journal of …, 2006 - search.ebscohost.com
The article examines the migratory responsiveness of macrophages to Acanthamoeba to
obtain insight into processes that are operative within the host that are affected by delta-9-…

Phytocannabinoids and the immune system

GA Cabral, ES Raborn, GA Ferreira - Handbook of Cannabis, 2014 - books.google.com
Phytocannabinoids are a class of compounds from the marijuana plant, Cannabis sativa.
These include the major nonpsychoactive components cannabidiol (CBD), cannabinol (CBN), …

Cannabinoid Modulation of Chemotaxis of Macrophages and Macrophage-like Cells

ES Raborn - 2007 - scholarscompass.vcu.edu
Exogenous and endogenous cannabinoids have been reported to modulate functional
activities of macrophages. It is recognized that macrophages express primarily the CB2 …