Ligands for glutamate receptors: design and therapeutic prospects

…, J Egebjerg, EØ Nielsen… - Journal of medicinal …, 2000 - ACS Publications
(S)-Glutamic acid (Glu), which is the main excitatory neurotransmitter in the central nervous
system (CNS), and other excitatory amino acids (EAAs) operate through four different classes …

2, 3-Dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline: a neuroprotectant for cerebral ischemia

MJ Sheardown, EØ Nielsen, AJ Hansen, P Jacobsen… - Science, 1990 - science.org
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the
quinoxalinedione antagonists to the non- N-methyl-D-aspartate (non-NMDA) glutamate receptor. …

Genomic analysis of PCV2 isolates from Danish archives and a current PMWS case–control study supports a shift in genotypes with time

K Dupont, EO Nielsen, P Baekbo, LE Larsen - Veterinary microbiology, 2008 - Elsevier
Porcine circovirus type 2 (PCV2) is the primary cause of Postweaning Multisystemic Wasting
Syndrome (PMWS) in pigs. PCV2, however, is found in both PMWS-affected herds and non-…

Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis

SF Nielsen, EØ Nielsen, GM Olsen… - Journal of medicinal …, 2000 - ACS Publications
In the past few years the focus on central acetylcholine receptors has shifted from compounds
with affinity for muscarinic acetylcholine receptors (mAChR) to compounds with affinity for …

An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

…, JH Grønlien, KL Kohlhaas, EØ Nielsen… - … of Pharmacology and …, 2007 - ASPET
Augmentation of nicotinic α7 receptor function is considered to be a potential therapeutic
strategy aimed at ameliorating cognitive and mnemonic dysfunction in relation to debilitating …

[HTML][HTML] Delineation of an endogenous zinc‐binding site in the human dopamine transporter

L Norregaard, D Frederiksen, EØ Nielsen… - The EMBO …, 1998 - embopress.org
The molecular basis for substrate translocation in the Na+/Cl−‐dependent neurotransmitter
transporters remains elusive. Here we report novel insight into the translocation mechanism …

Refinement and Evaluation of a Pharmacophore Model for Flavone Derivatives Binding to the Benzodiazepine Site of the GABAA Receptor

…, O Sterner, EØ Nielsen, M Nielsen… - Journal of Medicinal …, 2002 - ACS Publications
To further develop and evaluate a pharmacophore model previously proposed by Cook and
co-workers (Drug Des. Discovery 1995, 12, 193−248) for ligands binding to the …

Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1, 2, 3, 4-tetrahydro-1 …

…, US Sørensen, EØ Nielsen, KS Nielsen… - Molecular …, 2006 - ASPET
SK channels are small conductance Ca 2+ -activated K + channels important for the control
of neuronal excitability, the fine tuning of firing patterns, and the regulation of synaptic …

Augmentation of cognitive function by NS9283, a stoichiometry‐dependent positive allosteric modulator of α2‐and α4‐containing nicotinic acetylcholine receptors

DB Timmermann, K Sandager‐Nielsen… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Positive allosteric modulation of α4β2 nicotinic acetylcholine
(nACh) receptors could add a new dimension to the pharmacology and therapeutic …

[HTML][HTML] Evaluation of the relationship between the biosecurity status, production parameters, herd characteristics and antimicrobial usage in farrow-to-finish pig …

…, U Emanuelson, E grosse Beilage, EO Nielsen… - Porcine Health …, 2016 - Springer
Background High antimicrobial usage and the threat of antimicrobial resistance highlighted
the need for reduced antimicrobial usage in pig production. Prevention of disease however, …