Electrophysiological and pharmacological studies coupled with molecular identification have
revealed a unique network of ion channels—Kv1.3, KCa3.1, CRAC (Orai1 + Stim1), TRPM7…

Coccidioides is a fungal pathogen of humans which can cause a life-threatening respiratory
disease in immunocompetent individuals. Recurrent epidemics of coccidioidal infections in …

Background Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression
and function of Kv1.3 channels are required for the function of chronically activated …

The Kv1.3 channel is a recognized target for pharmaceutical development to treat autoimmune
diseases and organ rejection. ShK-186, a specific peptide inhibitor of Kv1.3, has shown …

Lacazia loboi is the last of the classical fungal pathogens to remain a taxonomic enigma,
primarily because it has resisted cultivation and only causes cutaneous and subcutaneous …

Sexual reproduction of fungi is governed by the mating type (MAT) locus, a specialized region
of the genome encoding key transcriptional regulators that direct regulatory networks to …

Coccidioidomycosis is a human respiratory disease that is endemic to the southwestern
United States and is caused by inhalation of the spores of a desert soilborne fungus. Efforts to …

Coccidioidomycosis is a respiratory disease of humans caused by the desert soil-borne
fungal pathogens Coccidioides spp. Recurrent epidemics of this mycosis in the southwestern …

Objectives Granulomatosis with polyangiitis (GPA) is a chronic relapsing systemic
autoimmune vasculitis. Current treatment of GPA is unsatisfactory, as it relies on strong …

LHF-535 is a small molecule antiviral currently in development for the treatment of Lassa
fever, a zoonotic disease endemic in West Africa that generates significant morbidity and …