Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

JD McKinney, KH Zu Bentrup, EJ Muñoz-Elías… - Nature, 2000 - nature.com
Mycobacterium tuberculosis claims more human lives each year than any other bacterial
pathogen. Infection is maintained in spite of acquired immunity and resists eradication by …

[HTML][HTML] Safety and pharmacodynamics of dalazatide, a Kv1. 3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

EJ Tarcha, CM Olsen, P Probst, D Peckham… - PloS one, 2017 - journals.plos.org
Background Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression
and function of Kv1.3 channels are required for the function of chronically activated …

Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

EJ Muñoz-Elías, JD McKinney - Nature medicine, 2005 - nature.com
Genes involved in fatty acid catabolism have undergone extensive duplication in the genus
Mycobacterium, which includes the etiologic agents of leprosy and tuberculosis. Here, we …

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide enhance IL-10 production by murine macrophages: in vitro and in vivo studies

M Delgado, EJ Munoz-Elias, RP Gomariz… - The Journal of …, 1999 - journals.aai.org
Vasoactive intestinal peptide (VIP), a neuropeptide present in the lymphoid microenvironment,
and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP) act …

VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNγ synthesis by T cells

M Delgado, EJ Munoz-Elias, RP Gomariz… - Journal of …, 1999 - Elsevier
Since IL-12 plays a central role against intracellular pathogens, and contributes to the
pathogenesis of immune diseases, its regulation is essential. This study examines the effect of two …

[HTML][HTML] Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit tumor necrosis factor α transcriptional activation by regulating …

M Delgado, EJ Munoz-Elias, Y Kan, I Gozes… - Journal of Biological …, 1998 - ASBMB
Tumor necrosis factor α (TNFα), an early cytokine produced by activated macrophages,
plays an essential role in normal and pathological inflammatory reactions. The excessive …

Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence

EJ Muñoz‐Elías, AM Upton, J Cherian… - Molecular …, 2006 - Wiley Online Library
Growth of bacteria and fungi on fatty acid substrates requires the catabolic β‐oxidation cycle
and the anaplerotic glyoxylate cycle. Propionyl‐CoA generated by β‐oxidation of odd‐chain …

Sc2S@Cs(10528)-C72: A Dimetallic Sulfide Endohedral Fullerene with a Non Isolated Pentagon Rule Cage

…, A Rodríguez-Fortea, EJ Munoz… - Journal of the …, 2012 - ACS Publications
A non isolated pentagon rule metallic sulfide clusterfullerene, Sc 2 S@C s (10528)-C 72 ,
has been isolated from a raw mixture of Sc 2 S@C 2n (n = 35–50) obtained by arc-discharging …

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide prevent inducible nitric oxide synthase transcription in macrophages by inhibiting …

M Delgado, EJ Munoz-Elias, RP Gomariz… - The Journal of …, 1999 - journals.aai.org
High-output nitric oxide (NO) production from activated macrophages, resulting from the
induction of inducible NO synthase (iNOS) expression, represents a major mechanism for …

Carbon metabolism of intracellular bacteria

EJ Muñoz‐Elías, JD McKinney - Cellular microbiology, 2006 - Wiley Online Library
Bacterial metabolism has been studied intensively since the first observations of these ‘animalcules’
by Leeuwenhoek and their isolation in pure cultures by Pasteur. Metabolic studies …