Activation of immune and inflammatory systems in chronic heart failure: novel therapeutic approaches

KZ Gong, G Song, JP Spiers, EJ Kelso… - … journal of clinical …, 2007 - Wiley Online Library
Despite extensive research and novel treatments, chronic heart failure (CHF) remains a cause
of high morbidity and mortality. Mounting evidence suggested that immune activation and …

Sex differences in fuel use and metabolism during development in fasting juvenile northern elephant seals

EJ Kelso, CD Champagne, MS Tift… - Journal of …, 2012 - journals.biologists.com
Many polygynous, capital breeders exhibit sexual dimorphism with respect to body size and
composition. Sexual dimorphism is often facilitated by sex differences in foraging behavior, …

Temporal characteristics of cardiomyocyte hypertrophy in the spontaneously hypertensive rat

D Bell, EJ Kelso, CCH Argent, GR Lee, AR Allen… - Cardiovascular …, 2004 - Elsevier
BACKGROUND: The spontaneously hypertensive rat (SHR) is frequently used as model of
cardiovascular disease, with considerable disparity in reported parameters of hypertrophy. …

Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade

JP Spiers, EJ Kelso, WF Siah, G Edge… - Journal of …, 2005 - journals.lww.com
Objective To determine the effects of age and dual endothelin (ET) A/ET B receptor antagonism
(bosentan) on aortic matrix metalloproteinase (MMP) abundance and tissue inhibitor of …

Induction of hypertrophic responsiveness of cardiomyocytes to neuropeptide Y in response to pressure overload

D Bell, AR Allen, EJ Kelso, A Balasubramaniam… - … of Pharmacology and …, 2002 - ASPET
To determine whether neuropeptide Y (NPY)-related mechanisms become activated with
progression of cardiac hypertrophy in vivo, protein mass and de novo protein synthesis (…

Protection of cardiomyocyte function by propofol during simulated ischemia is associated with a direct action to reduce pro-oxidant activity

BJ McDermott, S McWilliams, K Smyth, EJ Kelso… - Journal of molecular and …, 2007 - Elsevier
To demonstrate a direct protective effect of propofol on myocardial contractile performance
during an ischemic episode and investigate underlying mechanisms, isolated adult rat …

EndothelinA receptor subtype mediates endothelin-induced contractility in left ventricular cardiomyocytes isolated from rabbit myocardium

EJ Kelso, BJ McDermott, B Silke, JP Spiers - Journal of Pharmacology and …, 2000 - ASPET
Endothelin (ET)-1 is a potent positive inotropic agent, the effects of which are mediated by
increases in cytosolic Ca 2+ in the myocardium. The object of this study was to examine 1) the …

Modulation of contractile function through neuropeptide Y receptors during development of cardiomyocyte hypertrophy

AR Allen, EJ Kelso, D Bell, YY Zhao, P Dickson… - … of Pharmacology and …, 2006 - ASPET
Kelso, David Bell, YouYou Zhao, Paula Dickson and Barbara J. McDermott … procedure
used in the measurement of contraction amplitude were those described by Kelso et al. (2000). …

Upregulation of adrenomedullin and its receptor components during cardiomyocyte hypertrophy induced by chronic inhibition of nitric oxide synthesis in rats

D Bell, YY Zhao, EJ Kelso… - American Journal …, 2006 - journals.physiology.org
Adrenomedullin may provide a compensatory mechanism to attenuate left ventricular hypertrophy
(LVH). Nitric oxide synthase inhibition, induced by chronic administration of N ω -nitro-l…

Use of A-192621 to provide evidence for involvement of endothelin ETB-receptors in endothelin-1-mediated cardiomyocyte hypertrophy

JP Cullen, D Bell, EJ Kelso, BJ McDermott - European journal of …, 2001 - Elsevier
Increased plasma levels of endothelin-1 correlate with the severity of left ventricular hypertrophy
in vivo. The aim of the study was to determine the relative contribution of stimulation of …