Amiloride and its analogs as tools in the study of ion transport.

TR Kleyman, EJ Cragoe Jr - The Journal of membrane biology, 1988 - europepmc.org
Amiloride inhibits most plasma membrane Na+ transport systems. We have reviewed the
pharmacology of inhibition of these transporters by amiloride and its analogs. Thorough studies …

Participation of a K+ channel modulated directly by cGMP in the speract-induced signaling cascade of Strongylocentrotus purpuratus sea urchin sperm

BE Galindo, C Beltrán, EJ Cragoe Jr, A Darszon - Developmental biology, 2000 - Elsevier
Speract, a decapeptide from Strongylocentrotus purpuratus sea urchin eggs, transiently
stimulates a membrane guanylyl cyclase and activates a K + -selective channel that …

Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger

…, P Barbry, P Vigne, O Chassande, EJ Cragoe Jr… - Biochimie, 1988 - Elsevier
Amiloride analogs inhibit a number of transmembrane Na + transport systems: 1) the
epithelium Na + channel, 2) the Na + /H + exchange system and 3) the Na + /Ca 2+ exchange …

NMR measurements of Na+ and cellular energy in ischemic rat heart: role of Na (+)-H+ exchange

…, MC Madden, EJ Cragoe Jr… - American Journal …, 1993 - journals.physiology.org
… Cala, PM, SE Anderson, and EJ Cragoe. Na/H exchange-dependent cell volume and pH …
Kleyman, TR, and EJ Cragoe. Amiloride and its analogs as tools in the study of ion transport…

[HTML][HTML] An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.

…, S Brandon, AL Wilson, CA Guyer, EJ Cragoe Jr… - Journal of Biological …, 1990 - Elsevier
The residue involved in sodium regulation of G-protein-coupled receptors has been identified
by site-directed mutagenesis of the alpha 2-adrenergic receptor gene. Mutation of Asp-79 …

Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides

EJ Cragoe, OW Woltersdorf, JB Bicking… - Journal of medicinal …, 1967 - ACS Publications
The synthesis of a series of N-umidino-3-amino-5-substituted O-halopyrazinecarboxamides
is described. In rats and dogs, these compounds cause diuresis and saluresis while …

Purification and reconstitution of chloride channels from kidney and trachea

…, MH Akabas, C Redhead, A Edelman, EJ Cragoe Jr… - Science, 1989 - science.org
Chloride channels mediate absorption and secretion of fluid in epithelia, and the regulation
of these channels is now known to be defective in cystic fibrosis. Indanyl-oxyacetic acid 94 (…

The mechanism of action of amiloride.

TR Kleyman, EJ Cragoe Jr - Seminars in nephrology, 1988 - europepmc.org
Amiloride induces a mild natriuresis as well as antikaliuresis. These changes in salt excretion
are due to direct inhibition of the sodium channel in the apical plasma membrane of the …

Regulation of human neutrophil chemotaxis by intracellular pH.

L Simchowitz, EJ Cragoe Jr - Journal of Biological Chemistry, 1986 - Elsevier
The relationship of N-formyl-methionyl-leucyl-phenylalanine-stimulated Na+/H+ exchange
to the chemotactic responsiveness of human neutrophils was investigated. The pHi changes, …

[HTML][HTML] Regulation of intracellular pH in cultured hippocampal neurons by an amiloride-insensitive Na+/H+ exchanger.

KM Raley-Susman, EJ Cragoe Jr, RM Sapolsky… - Journal of Biological …, 1991 - Elsevier
Regulation of intracellular pH (pHi) in single cultured rat hippocampal neurons was investigated
using the fluorescent pHi indicator dye bis-carboxyethylcarboxyfluorescein. Resting pHi …