The ultrarapid delayed rectifier channels have attracted considerable interest as targets for ‘atrial-selective’
antiarrhythmic drugs because they contribute to atrial but not to ventricular …

Background: Advancing structural and functional maturation of stem cell–derived cardiomyocytes
remains a key challenge for applications in disease modeling, drug screening, and …

Background— The molecular mechanism of increased background inward rectifier current (I
K1 ) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active …

… The differences between peak outward current and late current were corrected for driving
force (En,-Ert,v, where E,,, is the potential of the test pulse and E,,, is the ussumed reversal …

Background Clinical and experimental evidence suggest that the parasympathetic nervous
system is involved in the pathogenesis of atrial fibrillation (AF). However, it is unclear whether …

… Erich Wettwer studied biology and did a PhD in Physiology investigating Ca homeostasis in
skeletal muscle cells. He joined Ursula Ravens' lab in Essen and continued to work with her …

Background— Although downregulation of L-type Ca 2+ current (I Ca,L ) in chronic atrial
fibrillation (AF) is an important determinant of electrical remodeling, the molecular mechanisms …

… The differences between peak outward current and late current were corrected fordriving
force (Em-Er,e,, where E, is the potential of the test pulse and Erev is the assumed reversal …

… In accordance with the model predictions, block of I Kr with E-4031 converted APD … block
with E-4031. A, Original AP registration in SR; C, control AP (solid line), 20 minutes after E-4031 …

… shows selective inhibition of I r without major block of I s (E; hMSC from 4th passage). …
clofilium shows selective inhibition of I s without major block of I r (E; hMSC from the 4th passage). …