Mice from 15 standard inbred strains were tested for sensitivity to two effects of acute morphine
administration, open-field activity, and body temperature changes, at doses of 0, 4, 8, 16, …

Cellular receptor dynamics are often analyzed using differential equations, making system
dynamics (SD) a candidate methodology. In some cases it may be useful to model the …

Rapid tolerance to rotarod ataxia has previously been demonstrated in mice after sequential
ethanol injections. Here we tested DBA/2J and C57BL/6J mice for initial ethanol sensitivity; …

The progesterone metabolite 3α-hydroxy-5α-pregnan-20-one (3α,5α-P or allopregnanolone)
is a potent positive modulator of γ-aminobutyric acid A (GABA A ) receptors. Although it is …

Background Marked lactic acidosis occurs during orthotopic liver transplantation (OLT),
especially during the anhepatic phase. Current standard therapy is NaHCO3, although it may …

End‐stage renal disease (ESRD) patients receiving hemodialysis are typically anemic due
to a lack of erythropoietin (EPO), a hormone required for red blood cell (RBC) production. …

Sensitivity and tolerance to ethanol-induced ataxia and hypothermia are determined in part
by genetic factors; some genes that affect one of these traits may affect others as well. To test …

… (EJ Gallaher, unpublished observations). The anticonvulsant effect of 3α,5α-THP was
reexamined in this study for two reasons; 1) an expanded dose range was evaluated and 2) the …

We have developed a precise quantal method for assessing the sensitivity to ethanol in the
mouse. Mice placed on a clamped stationary horizontal dowel are scored ataxi or not ataxic …

Objective To determine the value of a biomedical system dynamics (BMSD) approach for
optimization of anemia management in long-term hemodialysis patients because elevated …