User profiles for Duxin Sun
 | Duxin Sun, PhDAssociate Dean for Research and the Charles Walgreen Jr. Professor at the College of … Verified email at umich.edu Cited by 19305 |
[HTML][HTML] Why 90% of clinical drug development fails and how to improve it?
Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …
strategies, which raised the question whether certain aspects in target validation and drug …
Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds
The emergence of cancer stem cell theory has profound implications for cancer chemoprevention
and therapy. Cancer stem cells give rise to the tumor bulk through continuous self-…
and therapy. Cancer stem cells give rise to the tumor bulk through continuous self-…
Biodegradable self-assembled nanoparticles of poly (D, L-lactide-co-glycolide)/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer
…, D Wang, G Zhang, G Zhou, J Liu, Z Sun, D Sun… - Biomaterials, 2014 - Elsevier
To develop biodegradable docetaxel-loaded self-assembled nanoparticles of poly (d,l-lactide-co-glycolide)/hyaluronic
acid block copolymers were successfully synthesized. These …
acid block copolymers were successfully synthesized. These …
[HTML][HTML] Engineering exosomes as refined biological nanoplatforms for drug delivery
Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important
mediators of long distance intercellular communication and are involved in a diverse range of …
mediators of long distance intercellular communication and are involved in a diverse range of …
Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model
Purpose To study the correlation of intestinal absorption for drugs with various absorption
routes between human and rat, and to explore the underlying molecular mechanisms for the …
routes between human and rat, and to explore the underlying molecular mechanisms for the …
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
Purpose: The existence of cancer stem cells (CSCs) in breast cancer has profound implications
for cancer prevention. In this study, we evaluated sulforaphane, a natural compound …
for cancer prevention. In this study, we evaluated sulforaphane, a natural compound …
Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs
Purpose. To compare gene expression profiles and drug permeability differences in Caco-2
cell culture and human duodenum. Methods. Gene expression profiles in Caco-2 cells and …
cell culture and human duodenum. Methods. Gene expression profiles in Caco-2 cells and …
[HTML][HTML] A potent and selective small-molecule degrader of STAT3 achieves complete tumor regression in vivo
Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic
target. Here we report the discovery of SD-36, a small-molecule degrader of STAT3. SD-36 …
target. Here we report the discovery of SD-36, a small-molecule degrader of STAT3. SD-36 …
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
Pancreatic cancer is an aggressive disease with multiple biochemical and genetic alterations.
Thus, a single agent to hit one molecular target may not be sufficient to treat this disease. …
Thus, a single agent to hit one molecular target may not be sufficient to treat this disease. …
Discovery of a small-molecule degrader of bromodomain and extra-terminal (BET) proteins with picomolar cellular potencies and capable of achieving tumor …
The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3,
BRD4, and testis-specific BRDT members, are epigenetic “readers” and play a key role in the …
BRD4, and testis-specific BRDT members, are epigenetic “readers” and play a key role in the …