In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. V. Affinity maturation develops in two stages of clonal selection

Y Takahashi, PR Dutta, DM Cerasoli… - The Journal of …, 1998 - rupress.org
To examine the role of germinal centers (GCs) in the generation and selection of high
affinity antibody-forming cells (AFCs), we have analyzed the average affinity of (4-hydroxy-3-…

Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning

…, J Pierson, DK Hockley, DM Cerasoli… - Proceedings of the …, 2007 - National Acad Sciences
Dangerous organophosphorus (OP) compounds have been used as insecticides in agriculture
and in chemical warfare. Because exposure to OP could create a danger for humans in …

Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review

…, JR Smith, RE Sweeney, LA Lumley, DM Cerasoli - Toxicology, 2007 - Elsevier
Currently fielded treatments for nerve agent intoxication promote survival, but do not afford
complete protection against either nerve agent-induced motor and cognitive deficits or …

Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase

…, CL Cadieux, SA Kasten, TE Reeves, DM Cerasoli… - Biochemistry, 2010 - ACS Publications
Organophosphorus compounds include many synthetic, neurotoxic substances that are
commonly used as insecticides. The toxicity of these compounds is due to their ability to inhibit …

Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys

…, I Koplovitz, CR Clark, BR Capacio, DM Cerasoli… - Chemico-biological …, 2005 - Elsevier
Human butyrylcholinesterase (HuBuChE), purified from outdated human plasma, is being
evaluated for efficacy against nerve agents in guinea pigs and cynomolgus monkeys. Previous …

Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in bcl-xL Transgenic Mice

…, DM Cerasoli, JM Dal Porto, M Shimoda… - The Journal of …, 1999 - rupress.org
The role of apoptosis in affinity maturation was investigated by determining the affinity of (4-hydroxy-3-nitrophenyl)acetyl
(NP)-specific antibody-forming cells (AFCs) and serum antibody …

Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents

…, H Soreq, DE Lenz, DM Cerasoli… - Proceedings of the …, 2010 - National Acad Sciences
The concept of using cholinesterase bioscavengers for prophylaxis against organophosphorous
nerve agents and pesticides has progressed from the bench to clinical trial. However, …

Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents

…, CL Cadieux, CA Baker, TC Otto, DM Cerasoli… - Science translational …, 2019 - science.org
Nerve agents are a class of organophosphorus compounds (OPs) that blocks communication
between nerves and organs. Because of their acute neurotoxicity, it is extremely difficult to …

Production of ES1 plasma carboxylesterase knockout mice for toxicity studies

…, CM Timperley, LM Schopfer, DM Cerasoli… - Chemical research in …, 2011 - ACS Publications
The LD 50 for soman is 10–20-fold higher for a mouse than a human. The difference in
susceptibility is attributed to the presence of carboxylesterase in mouse but not in human plasma. …

Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model

…, BJ Bahnson, DE Lenz, DM Cerasoli - … et Biophysica Acta (BBA …, 2004 - Elsevier
Human serum paraoxonase (HuPON1) is a calcium-dependent enzyme that hydrolyzes
esters, including organophosphates and lactones, and exhibits anti-atherogenic properties. A …