User profiles for Douglas Cyr
 | Doug CyrDepartment of Cell Biology and Physiology, UNC Chapel Hill Verified email at med.unc.edu Cited by 14779 |
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
The folding of both wild-type and mutant forms of the cystic-fibrosis transmembrane-conductance
regulator (CFTR), a plasma-membrane chloride-ion channel, is inefficient 1, 2, 3, 4. …
regulator (CFTR), a plasma-membrane chloride-ion channel, is inefficient 1, 2, 3, 4. …
DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70
THE FUNCTION OF Hsp70 proteins as molecular chaperones in mediating the biogenesis
of proteins has been known for quite some time. The basic mechanism of action for these …
of proteins has been known for quite some time. The basic mechanism of action for these …
[HTML][HTML] CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation
J Jiang, CA Ballinger, Y Wu, Q Dai, DM Cyr… - Journal of Biological …, 2001 - ASBMB
Proper folding of proteins (either newly synthesized or damaged in response to a stressful
event) occurs in a highly regulated fashion. Cytosolic chaperones such as Hsc/Hsp70 are …
event) occurs in a highly regulated fashion. Cytosolic chaperones such as Hsc/Hsp70 are …
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations
…, RA Frizzell, DN Sheppard, DM Cyr… - Molecular biology of …, 2016 - Am Soc Cell Biol
More than 2000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR)
have been described that confer a range of molecular cell biological and functional …
have been described that confer a range of molecular cell biological and functional …
The J‐protein family: modulating protein assembly, disassembly and translocation
DnaJ is a molecular chaperone and the prototypical member of the J‐protein family. J proteins
are defined by the presence of a J domain that can regulate the activity of 70‐kDa heat‐…
are defined by the presence of a J domain that can regulate the activity of 70‐kDa heat‐…
[HTML][HTML] Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator
Cystic fibrosis arises from the misfolding and premature degradation of CFTRΔF508, a Cl −
ion channel with a single amino acid deletion. Yet, the quality-control machinery that selects …
ion channel with a single amino acid deletion. Yet, the quality-control machinery that selects …
YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism
The role of S. cerevisiae YDJ1 protein (YDJ1p) in polypeptide translocation across membranes
has been examined. A conditional ydj1 mutant strain (ydj1-151 TS ) is defective for …
has been examined. A conditional ydj1 mutant strain (ydj1-151 TS ) is defective for …
[HTML][HTML] Mechanisms for regulation of Hsp70 function by Hsp40
The Hsp70 family members play an essential role in cellular protein metabolism by acting
as polypeptide-binding and release factors that interact with nonnative regions of proteins at …
as polypeptide-binding and release factors that interact with nonnative regions of proteins at …
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold
DM Cyr, J Höhfeld, C Patterson - Trends in biochemical sciences, 2002 - cell.com
Molecular chaperones act with folding co-chaperones to suppress protein aggregation and
refold stress damaged proteins. However, it is not clear how slowly folding or misfolded …
refold stress damaged proteins. However, it is not clear how slowly folding or misfolded …
[HTML][HTML] From the cradle to the grave: molecular chaperones that may choose between folding and degradation
J Höhfeld, DM Cyr, C Patterson - EMBO reports, 2001 - embopress.org
Molecular chaperones are known to facilitate cellular protein folding. They bind non‐native
proteins and orchestrate the folding process in conjunction with regulatory cofactors that …
proteins and orchestrate the folding process in conjunction with regulatory cofactors that …