User profiles for Dong Jin Hwang

Dong-Jin Hwang

UTHSC
Verified email at uthsc.edu
Cited by 2377

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

…, CC Coss, R Narayanan, Y He, DJ Hwang… - Journal of medicinal …, 2009 - ACS Publications
Interest in the development and therapeutic potential of nonsteroidal tissue-selective
androgen receptor modulators (SARMs) a has increased dramatically within the past decade. …

Recent and emerging anti‐diabetes targets

ML Mohler, Y He, Z Wu, DJ Hwang… - Medicinal research …, 2009 - Wiley Online Library
Diabetes is a disease that affects over 150 million people worldwide for which there are
multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, …

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy

…, H Chen, S Deng, DJ Hwang… - Medicinal research …, 2019 - Wiley Online Library
Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

A potent, metabolically stable tubulin inhibitor targets the colchicine binding site and overcomes taxane resistance

KE Arnst, Y Wang, DJ Hwang, Y Xue, T Costello… - Cancer research, 2018 - AACR
Antimitotics that target tubulin are among the most useful chemotherapeutic drugs, but their
clinical activity is often limited by the development of multidrug resistance. We recently …

Inhibiting androgen receptor splice variants with cysteine-selective irreversible covalent inhibitors to treat prostate cancer

…, S Ponnusamy, DJ Hwang… - Proceedings of the …, 2023 - National Acad Sciences
Androgen receptor (AR) and its splice variants (AR-SVs) promote prostate cancer (PCa)
growth by orchestrating transcriptional reprogramming. Mechanisms by which the low …

Novel selective agents for the degradation of androgen receptor variants to treat castration-resistant prostate cancer

…, CC Coss, T Thiyagarajan, K Watts, DJ Hwang… - Cancer Research, 2017 - AACR
Androgen receptor (AR) mediates the growth of prostate cancer throughout its course of
development, including in abnormal splice variants (AR-SV)-driven advanced stage castration-…

[HTML][HTML] An overview of next-generation androgen receptor-targeted therapeutics in development for the treatment of prostate cancer

ML Mohler, A Sikdar, S Ponnusamy, DJ Hwang… - International journal of …, 2021 - mdpi.com
Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of
the androgen receptor (AR) signaling axis since Huggins et al. discovered that …

Structural optimization of indole derivatives acting at colchicine binding site as potential anticancer agents

DJ Hwang, J Wang, W Li, DD Miller - ACS medicinal chemistry …, 2015 - ACS Publications
A new series of indole analogues based on our earlier lead compound, 2-(1H-indol-5-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine
(42), was prepared as tubulin inhibitors in …

The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition …

J Kim, D Wu, DJ Hwang, DD Miller, JT Dalton - Journal of Pharmacology and …, 2005 - ASPET
Selective androgen receptor modulators (SARMs) have many potential therapeutic applications,
including male hypogonadism, osteoporosis, muscle-wasting diseases, sexual libido, …

A selective androgen receptor modulator for hormonal male contraception

J Chen, DJ Hwang, CE Bohl, DD Miller… - Journal of Pharmacology …, 2005 - ASPET
The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs)
provides a promising alternative for testosterone replacement therapies, including hormonal …