User profiles for Dong Jin Hwang
Dong-Jin HwangUTHSC Verified email at uthsc.edu Cited by 2377 |
Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit
Interest in the development and therapeutic potential of nonsteroidal tissue-selective
androgen receptor modulators (SARMs) a has increased dramatically within the past decade. …
androgen receptor modulators (SARMs) a has increased dramatically within the past decade. …
Recent and emerging anti‐diabetes targets
ML Mohler, Y He, Z Wu, DJ Hwang… - Medicinal research …, 2009 - Wiley Online Library
Diabetes is a disease that affects over 150 million people worldwide for which there are
multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, …
multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, …
Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy
Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …
A potent, metabolically stable tubulin inhibitor targets the colchicine binding site and overcomes taxane resistance
KE Arnst, Y Wang, DJ Hwang, Y Xue, T Costello… - Cancer research, 2018 - AACR
Antimitotics that target tubulin are among the most useful chemotherapeutic drugs, but their
clinical activity is often limited by the development of multidrug resistance. We recently …
clinical activity is often limited by the development of multidrug resistance. We recently …
Inhibiting androgen receptor splice variants with cysteine-selective irreversible covalent inhibitors to treat prostate cancer
…, S Ponnusamy, DJ Hwang… - Proceedings of the …, 2023 - National Acad Sciences
Androgen receptor (AR) and its splice variants (AR-SVs) promote prostate cancer (PCa)
growth by orchestrating transcriptional reprogramming. Mechanisms by which the low …
growth by orchestrating transcriptional reprogramming. Mechanisms by which the low …
Novel selective agents for the degradation of androgen receptor variants to treat castration-resistant prostate cancer
Androgen receptor (AR) mediates the growth of prostate cancer throughout its course of
development, including in abnormal splice variants (AR-SV)-driven advanced stage castration-…
development, including in abnormal splice variants (AR-SV)-driven advanced stage castration-…
[HTML][HTML] An overview of next-generation androgen receptor-targeted therapeutics in development for the treatment of prostate cancer
Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of
the androgen receptor (AR) signaling axis since Huggins et al. discovered that …
the androgen receptor (AR) signaling axis since Huggins et al. discovered that …
Structural optimization of indole derivatives acting at colchicine binding site as potential anticancer agents
A new series of indole analogues based on our earlier lead compound, 2-(1H-indol-5-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine
(42), was prepared as tubulin inhibitors in …
(42), was prepared as tubulin inhibitors in …
The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition …
Selective androgen receptor modulators (SARMs) have many potential therapeutic applications,
including male hypogonadism, osteoporosis, muscle-wasting diseases, sexual libido, …
including male hypogonadism, osteoporosis, muscle-wasting diseases, sexual libido, …
A selective androgen receptor modulator for hormonal male contraception
The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs)
provides a promising alternative for testosterone replacement therapies, including hormonal …
provides a promising alternative for testosterone replacement therapies, including hormonal …