Synthesis of chiral 0-amido esters 7 with high diastereoisomeric excess was achieved by
asymmetric hydrogenation (H2/Pt02) of stereogenic/S-acetamidocrotonates 6 in which the …

LFA-1 (leukocyte function-associated antigen-1), is a member of the β2-integrin family and
is expressed on all leukocytes. This letter describes the discovery and preliminary SAR of …

Protein kinase Cθ (PKCθ) regulates a key step in the activation of T cells. On the basis of its
mechanism of action, inhibition of this kinase is hypothesized to serve as an effective therapy …

LFA-1 appears to play a central role in normal immune responses to foreign Ags. In
autoimmune or inflammatory diseases, there is increased expression of LFA-1 and/or its …

Leukocyte function-associated antigen-1 (LFA-1), also known as CD11a/CD18 or α L β 2 ,
belongs to the β 2 integrin subfamily and is constitutively expressed on all leukocytes. The …

A high-throughput screen against Inventiva’s compound library using a Gal4/RORγ-LBD
luciferase reporter gene assay led to the discovery of a new series of quinoline sulphonamides …

Morphing structural features of HTS-derived chemotypes led to the discovery of novel 2-cyano-pyrimidine
inhibitors of cathepsin K with good pharmacokinetic profiles, for example, …

LFA-1 (leukocyte function-associated antigen-1), is a member of the β 2 -integrin family and
is expressed on all leukocytes. The LFA-1/ICAM interaction promotes tight adhesion …

A new class of lymphocyte function-associated antigen-1 (LFA-1) antagonists is described.
Elaboration of the 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold resulted in the synthesis of …

2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors - ScienceDirect
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