User profiles for Dmitri Simberg

Dmitri Simberg

University of Colorado Anschutz Medical Campus
Verified email at cuanschutz.edu
Cited by 5754

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

…, DS Backos, LP Wu, SM Moghimi, D Simberg - Nature …, 2017 - nature.com
When nanoparticles are intravenously injected into the body, complement proteins deposit
on the surface of nanoparticles in a process called opsonization. These proteins prime the …

Biomimetic amplification of nanoparticle homing to tumors

D Simberg, T Duza, JH Park, M Essler… - Proceedings of the …, 2007 - National Acad Sciences
Nanoparticle-based diagnostics and therapeutics hold great promise because multiple functions
can be built into the particles. One such function is an ability to home to specific sites in …

[HTML][HTML] Roadmap and strategy for overcoming infusion reactions to nanomedicines

J Szebeni, D Simberg, Á González-Fernández… - Nature …, 2018 - nature.com
Infusion reactions (IRs) are complex, immune-mediated side effects that mainly occur within
minutes to hours of receiving a therapeutic dose of intravenously administered …

Mechanisms and barriers in cancer nanomedicine: addressing challenges, looking for solutions

…, JH Park, D Peer, E Ruoslahti, NJ Serkova, D Simberg - 2017 - ACS Publications
Remarkable progress has recently been made in the synthesis and characterization of
engineered nanoparticles for imaging and treatment of cancers, resulting in several promising …

Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles

…, R Scheinman, L Saba, SM Moghimi, D Simberg - Nature …, 2019 - nature.com
Deposition of complement factors (opsonization) on nanoparticles may promote clearance
from the blood by macrophages and trigger proinflammatory responses, but the mechanisms …

Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems

PP Karmali, D Simberg - Expert opinion on drug delivery, 2011 - Taylor & Francis
Introduction: Intravenously injected nanoparticles, like any other foreign pathogen that
enters the body, encounter multiple lines of defense intended to neutralize and eliminate the …

Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting

…, G von Maltzahn, L Zhang, AM Derfus, D Simberg… - small, 2009 - Wiley Online Library
In the design of nanoparticles that can target disease tissue in vivo, parameters such as
targeting ligand density, type of target receptor, and nanoparticle shape can play an important …

[HTML][HTML] Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

LP Wu, M Ficker, JB Christensen, D Simberg… - Nature …, 2021 - nature.com
Complement is an enzymatic humoral pattern-recognition defence system of the body. Non-specific
deposition of blood biomolecules on nanomedicines triggers complement activation …

DOTAP (and other cationic lipids): chemistry, biophysics, and transfection

D Simberg, S Weisman, Y Talmon… - Critical Reviews™ in …, 2004 - dl.begellhouse.com
Cationic lipid-mediated nucleic acid and protein delivery is becoming increasingly popular for
in vitro and in vivo applications. While the chemistry of cationic lipid carriers is moving very …

Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance

D Simberg, JH Park, PP Karmali, WM Zhang… - Biomaterials, 2009 - Elsevier
In order to understand the role of plasma proteins in the rapid liver clearance of dextran-coated
superparamagnetic iron oxide (SPIO) in vivo, we analyzed the full repertoire of SPIO-…