The distribution of cholecystokinin immunoreactivity in the central nervous system of the rat as determined by radioimmunoassay

MC Beinfeld, DK Meyer, RL Eskay, RT Jensen… - Brain research, 1981 - Elsevier
The regional distribution of cholecystokinin (CCK) in the rat brain was determined utilizing a
radioimmunoassay which detects both gastrin and CCK. CCK concentration is highest in the …

[HTML][HTML] Cellular uptake of Clostridium difficile toxin B: translocation of the N-terminal catalytic domain into the cytosol of eukaryotic cells

…, J Leemhuis, C Busch, DK Meyer, K Aktories… - Journal of Biological …, 2003 - ASBMB
Clostridium difficile toxin B (269 kDa) is one of the causative agents of antibiotic-associated
diarrhea and pseudomembranous colitis. Toxin B acts in the cytosol of eukaryotic target cells …

[HTML][HTML] The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

…, J Leemhuis, D Tiemann, DK Meyer, K Aktories… - Journal of Biological …, 2003 - ASBMB
Clostridium botulinum C2 toxin is the prototype of the binary actin-ADP-ribosylating toxins
and consists of the binding component C2II and the enzyme component C2I. The activated …

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

…, F Henle, L Hein, J Herz, DK Meyer… - Journal of …, 2010 - Soc Neuroscience
Lipoprotein receptor signaling regulates the positioning and differentiation of postmitotic
neurons during development and modulates neuronal plasticity in the mature brain. Depending …

Cellular Uptake of Clostridium botulinum C2 Toxin:  Membrane Translocation of a Fusion Toxin Requires Unfolding of Its Dihydrofolate Reductase Domain

G Haug, C Wilde, J Leemhuis, DK Meyer, K Aktories… - Biochemistry, 2003 - ACS Publications
The Clostridium botulinum C2 toxin is the prototype of the family of binary actin−ADP-ribosylating
toxins. C2 toxin is composed of two separated nonlinked proteins. The enzyme …

The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase

J Leemhuis, S Boutillier, G Schmidt, DK Meyer - Journal of Pharmacology …, 2002 - ASPET
The small GTPase RhoA can retract cell extensions by acting on two Rho kinases (ROCKs).
Activated protein kinase A (PKA) inhibits RhoA and induces extensions. The isoquinoline …

Effect of transection of subfornical organ efferent projections on vasopressin release induced by angiotensin or isoprenaline in the rat

W Knepel, D Nutto, DK Meyer - Brain research, 1982 - Elsevier
Transection of subfornical organ efferents in the rat prevented the vasopressin release in
response to intravenous angiotensin II infusion or following a small dose of the β-…

[HTML][HTML] Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites

…, C Brock, B Nurnberg, K Aktories, DK Meyer - Journal of Biological …, 2004 - ASBMB
Neurons receive information from other neurons via their dendritic tree. Dendrites and their
branches result from alternating outgrowth and retraction. The Rho GTPases Rac and Cdc42 …

Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain

C Olenik, H Barth, I Just, K Aktories, DK Meyer - Molecular brain research, 1997 - Elsevier
GTPases of the Rho subfamily, ie Rho, Rac and Cdc42, are molecular switches in various
signaling pathways. Best characterized are their functions in the regulation of the actin …

Differential expression of the small GTP-binding proteins RhoA, RhoB, Cdc42u and Cdc42b in developing rat neocortex

C Olenik, K Aktories, DK Meyer - Molecular brain research, 1999 - Elsevier
Studies with cultured cells indicate that small GTPases of the Rho family may be involved in
cell proliferation, differentiation, as well as migration. Therefore, we have studied the …