[HTML][HTML] Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation

M Akhtar, Y Chen, Z Ma, X Zhang, D Shi, JA Khan… - Animal Nutrition, 2022 - Elsevier
Gut inflammation is a challenging concern in humans and animals, which disturbs normal
growth and leads to severe bowel diseases. Short chain fatty acids (SCFA) are the gut …

Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel

D Shi, J Yang, D Yang, EL LeCluyse, C Black… - … of Pharmacology and …, 2006 - ASPET
Oseltamivir is the main medicine recommended by the World Health Organization in anticipation
of next influenza pandemic. This anti-influenza viral agent is an ester prodrug, and the …

Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol

…, EL LeCluyse, C Black, D Yang, D Shi… - … of Pharmacology and …, 2006 - ASPET
Aspirin (acetylsalicylic acid) and clopidogrel are two major antithrombogenic agents that are
widely used for the treatment and prevention of cerebro- and cardiovascular conditions …

[HTML][HTML] Short Chain Fatty Acids (SCFAs) Are the Potential Immunomodulatory Metabolites in Controlling Staphylococcus aureus-Mediated Mastitis

…, Q Liu, H Pan, Z Ma, N Kong, Y Chen, D Shi… - Nutrients, 2022 - mdpi.com
Mastitis is an emerging health concern in animals. An increased incidence of mastitis in dairy
cows has been reported in the last few years across the world. It is estimated that up to 20…

[HTML][HTML] Chicken jejunal microbiota improves growth performance by mitigating intestinal inflammation

X Zhang, M Akhtar, Y Chen, Z Ma, Y Liang, D Shi… - Microbiome, 2022 - Springer
Background Intestinal inflammation is prevalent in chicken, which results in decreased growth
performance and considerable economic losses. Accumulated findings established the …

Development of an immunochromatographic lateral-flow test strip for rapid detection of sulfonamides in eggs and chicken muscles

X Wang, K Li, D Shi, N Xiong, X Jin… - Journal of agricultural …, 2007 - ACS Publications
A rapid immunochromatographic lateral-flow test strip was developed in the competitive
reaction format for the detection of sulfonamides in eggs and chicken muscle. A monoclonal …

[HTML][HTML] Fecal microbiota transplantation improves chicken growth performance by balancing jejunal Th17/Treg cells

…, M Akhtar, H Pan, Q Liu, Y Chen, X Zhou, Y You, D Shi… - Microbiome, 2023 - Springer
Background Intestinal inflammation has become a threatening concern in chicken production
worldwide and is closely associated with Th17/Treg cell imbalance. Several studies …

The inflammation regulation effects of Enterococcus faecium HDRsEf1 on human enterocyte-like HT-29 cells

…, J Peng, X Wang, Z Li, M Liu, D Bi, D Shi - Animal cells and …, 2016 - Taylor & Francis
Enterococcus faecium HDRsEf1 strain used as a probiotic to inhibit intestine inflammation
and improve animal growth performance has been proved by our research team; however, it …

Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes

J Yang, C Hao, D Yang, D Shi, X Song, X Luan, G Hu… - Toxicology letters, 2010 - Elsevier
Cytochrome P450 3A4 (CYP3A4) is the most abundant cytochrome P450 enzyme in human
liver and metabolizes more than 60% of prescribed drugs in human body. Patients with liver …

Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2

J Yang, D Shi, D Yang, X Song, B Yan - Molecular pharmacology, 2007 - ASPET
Carboxylesterases constitute a class of enzymes that play important roles in the hydrolytic
metabolism of drugs and other xenobiotics. Patients with liver conditions such as cirrhosis …