Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
…, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee… - Diabetes, 1999 - Am Diabetes Assoc
To examine the mechanism by which free fatty acids (FFAs) induce insulin resistance in vivo,
awake chronically catheterized rats underwent a hyperinsulinemic-euglycemic clamp with …
awake chronically catheterized rats underwent a hyperinsulinemic-euglycemic clamp with …
Characterization of apelin, the ligand for the APJ receptor
DK Lee, R Cheng, T Nguyen, T Fan… - Journal of …, 2000 - Wiley Online Library
The apelin peptide was recently discovered and demonstrated to be the endogenous ligand
for the G protein‐coupled receptor, APJ. A search of the GenBank databases retrieved a rat …
for the G protein‐coupled receptor, APJ. A search of the GenBank databases retrieved a rat …
[HTML][HTML] B cell depletion therapies in autoimmune disease: advances and mechanistic insights
DSW Lee, OL Rojas, JL Gommerman - Nature reviews Drug discovery, 2021 - nature.com
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
Discovery of a receptor related to the galanin receptors
DK Lee, T Nguyen, GP O'Neill, R Cheng, Y Liu… - FEBS …, 1999 - Wiley Online Library
We report the isolation of a cDNA clone named GPR54, which encodes a novel G protein‐coupled
receptor (GPCR). A PCR search of rat brain cDNA retrieved a clone partially …
receptor (GPCR). A PCR search of rat brain cDNA retrieved a clone partially …
Deep imitation learning for complex manipulation tasks from virtual reality teleoperation
Imitation learning is a powerful paradigm for robot skill acquisition. However, obtaining
demonstrations suitable for learning a policy that maps from raw pixels to actions can be …
demonstrations suitable for learning a policy that maps from raw pixels to actions can be …
Identification and cloning of three novel human G protein-coupled receptor genes GPR52, ΨGPR53 and GPR55: GPR55 is extensively expressed in human brain
M Sawzdargo, T Nguyen, DK Lee, KR Lynch… - Molecular brain …, 1999 - Elsevier
The G protein-coupled receptor (GPCR) family share a structural motif of seven transmembrane
segments with large numbers of conserved residues in those regions. Here, we report …
segments with large numbers of conserved residues in those regions. Here, we report …
Discovery of a novel member of the histamine receptor family
…, V Setola, DK Lee, R Cheng, L Rauser, SP Lee… - Molecular …, 2001 - ASPET
We report the discovery, tissue distribution and pharmacological characterization of a novel
receptor, which we have named H4. Like the three histamine receptors reported previously (…
receptor, which we have named H4. Like the three histamine receptors reported previously (…
Are there pre-existing neural, cognitive, or motoric markers for musical ability?
Adult musician’s brains show structural enlargements, but it is not known whether these are
inborn or a consequence of long-term training. In addition, music training in childhood has …
inborn or a consequence of long-term training. In addition, music training in childhood has …
Modification of the terminal residue of apelin-13 antagonizes its hypotensive action
DK Lee, VR Saldivia, T Nguyen, R Cheng… - …, 2005 - academic.oup.com
The apelin peptide is the endogenous ligand for the apelin G protein-coupled receptor. The
distribution of the apelin peptides and receptor are widespread in the central nervous system …
distribution of the apelin peptides and receptor are widespread in the central nervous system …
Fibre-based composites from the integration of metal–organic frameworks and polymers
The integration of metal–organic frameworks (MOFs) with polymer fibres enables the
formation of fibrous composite materials with advantages over traditional single-component …
formation of fibrous composite materials with advantages over traditional single-component …