User profiles for Debomoy K. Lahiri
 | Debomoy K LahiriDistinguished Professor, Indiana University School Medicine, Indianapolis, USA Verified email at iupui.edu Cited by 33103 |
Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain
A Becaria, DK Lahiri, SC Bondy, DM Chen… - Journal of …, 2006 - Elsevier
Inflammatory and oxidative events are up-regulated in the brain of AD patients. It has been
reported that in animal models of AD, exposure to aluminum (Al) or copper (Cu) enhanced …
reported that in animal models of AD, exposure to aluminum (Al) or copper (Cu) enhanced …
A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies.
DK Lahiri, JI Nurnberger Jr - Nucleic acids research, 1991 - ncbi.nlm.nih.gov
RESULTS AND DISCUSSION 1. In our hands, this procedure yields more DNA than any
other methods (1-5), generally in the range of 130-160. tg from 5 ml of blood. We have also …
other methods (1-5), generally in the range of 130-160. tg from 5 ml of blood. We have also …
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent
…, K Sambamurti, A Brossi, DK Lahiri - Proceedings of the …, 2005 - National Acad Sciences
Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter
acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is …
acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is …
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
…, K Sambamurti, A Brossi, DK Lahiri… - Proceedings of the …, 2009 - National Acad Sciences
Glucagon-like peptide-1 (GLP-1) is an endogenous insulinotropic peptide secreted from the
gastrointestinal tract in response to food intake. It enhances pancreatic islet β-cell …
gastrointestinal tract in response to food intake. It enhances pancreatic islet β-cell …
[HTML][HTML] An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
Iron-responsive elements (IREs) are the RNA stem loops that control cellular iron homeostasis
by regulating ferritin translation and transferrin receptor mRNA stability. We mapped a …
by regulating ferritin translation and transferrin receptor mRNA stability. We mapped a …
A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly,
characterised by widespread loss central cholinergic function. The only symptomatic treatment …
characterised by widespread loss central cholinergic function. The only symptomatic treatment …
Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and …
The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may
drive AD pathogenesis; however, the triggering factors and the period of their action are …
drive AD pathogenesis; however, the triggering factors and the period of their action are …
Butyrylcholinesterase: an important new target in Alzheimer's disease therapy
Acetylcholinesterase (AChE) predominates in the healthy brain, with butyrylcholinesterase (BuChE)
considered to play a minor role in regulating brain acetylcholine (ACh) levels. …
considered to play a minor role in regulating brain acetylcholine (ACh) levels. …
DNA isolation by a rapid method from human blood samples: Effects of MgCl2, EDTA, storage time, and temperature on DNA yield and quality
DK Lahiri, B Schnabel - Biochemical genetics, 1993 - Springer
The isolation of DNA from whole blood by a modified rapid method (RM) was tested using
various detergents and buffer conditions. Extraction of DNA with either NP-40 or Triton X-100 …
various detergents and buffer conditions. Extraction of DNA with either NP-40 or Triton X-100 …
The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and β-amyloid in the aging brain
…, N Benitez, HK Siddiqi, YW Ge, DK Lahiri… - Journal of …, 2005 - Soc Neuroscience
The fetal basis of adult disease (FeBAD) hypothesis states that many adult diseases have a
fetal origin. According to FeBAD, injury or environmental influences occurring at critical …
fetal origin. According to FeBAD, injury or environmental influences occurring at critical …