Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histones
and other proteins and in regulating fundamental cellular activities such as transcription. …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

▪ Abstract Increasing evidence supports the notion that glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) is a protein with multiple functions, including its surprising role in …

This report describes a modulatory action of lithium and glutamate on the activity of serine/threonine
kinase Akt-1. Lithium is most commonly used to treat bipolar disorder, but the …

The pathophysiology of cerebral ischemia involves multiple mechanisms including
neuroinflammation mediated by activated microglia and infiltrating macrophages/monocytes. The …

This study was undertaken to investigate the molecular mechanisms underlying the
neuroprotective actions of lithium against glutamate excitotoxicity with a focus on the role of …

Lithium is the most commonly used drug for the treatment of manic depressive illness. The
precise mechanisms underlying its clinical efficacy remain unknown. We found that long-term …

In the healthy adult brain, neurogenesis normally occurs in the subventricular zone (SVZ)
and hippocampal dentate gyrus (DG). Cerebral ischemia enhances neurogenesis in …

Growing evidence from in vitro studies supports that valproic acid (VPA), an anti‐convulsant
and mood‐stabilizing drug, has neuroprotective effects. The present study investigated …

The therapeutic mechanisms of lithium for treating bipolar mood disorder remain poorly
understood. Recent studies demonstrate that lithium has neuroprotective actions against a …