Introduction: Parts A and B of the ICH S7 guidelines on safety pharmacology describe the in
vivo studies that must be conducted prior to first time in man administration of any new …

Current diagnosis of drug-induced kidney injury (DIKI) primarily relies on detection of elevated
plasma creatinine (Cr) or blood urea nitrogen (BUN) levels; however, both are indices of …

INTRODUCTION: A novel automated blood sampling and telemetry (ABST) system was
developed to integrate pharmacokinetic (PK), pharmacodynamic (PD) and toxicology studies. …

The tachykinins, substance P, neurokinin A, and neurokinin B, have been implicated in
many diseases. The present study evaluated the pharmacological properties of a novel …

Background and Purpose While the molecular pathways of baclofen toxicity are understood,
the relationships between baclofen‐mediated perturbation of individual target organs and …

Background A successful integration of the automated blood sampling (ABS) and telemetry (ABST)
system is described. The new ABST system facilitates concomitant collection of …

Aerosol administration of neurokinin A (NKA) or substance P (SP) to conscious guinea pigs
produced labored abdominal breathing (dydpnea). Time to onset of dyspnea was inversely …

The search for antagonists of the leukotrienes or inhibitors of their production by the enzyme
5-lipoxygenase began in earnest over a decade ago following the disclosure of the …

The purpose of this paper is to establish the similarities and differences between the Internet
of Things (IoT) and the Internet of Everything (IoE). With the recent developments in the IoE, …

Previously, we have reported observing photoinduced elec-tron-transfer reactions on exciting
the low-lying metal-to-ligand charge-transfer excited state (s) of bis (2, 9-dimethyl-1, 10-…