User profiles for Daniel Scotcher
Daniel ScotcherUniversity of Manchester Verified email at manchester.ac.uk Cited by 482 |
Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease
…, M Fedecostante, D Scotcher… - Molecular …, 2019 - ACS Publications
Indoxyl sulfate (IxS), a highly albumin-bound uremic solute, accumulates in chronic kidney
disease (CKD) due to reduced renal clearance. This study was designed to specifically …
disease (CKD) due to reduced renal clearance. This study was designed to specifically …
Microsomal and cytosolic scaling factors in dog and human kidney cortex and application for in vitro-in vivo extrapolation of renal metabolic clearance
D Scotcher, S Billington, J Brown, CR Jones… - Drug Metabolism and …, 2017 - ASPET
In vitro-in vivo extrapolation of drug metabolism data obtained in enriched preparations of
subcellular fractions rely on robust estimates of physiologically relevant scaling factors for the …
subcellular fractions rely on robust estimates of physiologically relevant scaling factors for the …
[HTML][HTML] Key to Opening Kidney for In Vitro–In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data
D Scotcher, C Jones, M Posada, A Rostami-Hodjegan… - The AAPS journal, 2016 - Springer
… of mechanistic models of renal drug excretion and/or metabolism, including the dynamics of
drug disposition in kidney cells and the need for appropriate clinical data (Scotcher D, Jones …
drug disposition in kidney cells and the need for appropriate clinical data (Scotcher D, Jones …
[HTML][HTML] Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation
D Scotcher, C Jones, M Posada, A Galetin… - The AAPS journal, 2016 - Springer
It is envisaged that application of mechanistic models will improve prediction of changes in
renal disposition due to drug-drug interactions, genetic polymorphism in enzymes and …
renal disposition due to drug-drug interactions, genetic polymorphism in enzymes and …
Scaling factors for clearance in adult liver cirrhosis
In vitro to in vivo extrapolation (IVIVE) enables prediction of in vivo clinical outcomes related
to drug exposure in various populations from in vitro data. Prudent IVIVE requires scalars …
to drug exposure in various populations from in vitro data. Prudent IVIVE requires scalars …
Physiologically‐based pharmacokinetic modelling of creatinine‐drug interactions in the chronic kidney disease population
H Takita, D Scotcher, R Chinnadurai… - CPT …, 2020 - Wiley Online Library
Elevated serum creatinine (S Cr ) caused by the inhibition of renal transporter(s) may be
misinterpreted as kidney injury. The interpretation is more complicated in patients with chronic …
misinterpreted as kidney injury. The interpretation is more complicated in patients with chronic …
Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin
ABC transporters (ATP‐binding cassette transporter) traffic drugs and their metabolites across
membranes, making ABC transporter expression levels a key factor regulating local drug …
membranes, making ABC transporter expression levels a key factor regulating local drug …
Quantitative proteomic map of enzymes and transporters in the human kidney: stepping closer to mechanistic kidney models to define local kinetics
The applications of translational modeling of local drug concentrations in various organs
had a sharp increase over the last decade. These are part of the model‐informed drug …
had a sharp increase over the last decade. These are part of the model‐informed drug …
Mechanistic models as framework for understanding biomarker disposition: prediction of creatinine‐drug interactions
D Scotcher, V Arya, X Yang, P Zhao… - CPT …, 2020 - Wiley Online Library
Creatinine is widely used as a biomarker of glomerular filtration, and, hence, renal function.
However, transporter‐mediated secretion also contributes to its renal clearance, albeit to a …
However, transporter‐mediated secretion also contributes to its renal clearance, albeit to a …
Delineating the role of various factors in renal disposition of digoxin through application of physiologically based kidney model to renal impairment populations
D Scotcher, CR Jones, A Galetin… - Journal of Pharmacology …, 2017 - ASPET
Development of submodels of organs within physiologically-based pharmacokinetic (PBPK)
principles and beyond simple perfusion limitations may be challenging because of …
principles and beyond simple perfusion limitations may be challenging because of …