Electrophysiological devices are critical for mapping eloquent and diseased brain regions
and for therapeutic neuromodulation in clinical settings and are extensively used for research …

Deep brain stimulation (DBS) in the internal segment of the globus pallidus (GPi) relieves the
motor symptoms of Parkinson's disease, yet the mechanism of action remains uncertain. To …

The Utah array powers cutting‐edge projects for restoration of neurological function, such as
BrainGate, but the underlying electrode technology has itself advanced little in the last three …

Fossil records showing trephination in the Stone Age provide evidence that humans have
sought to influence the mind through physical means since before the historical record. …

μ-Opioid agonists frequently activate output neurons in the brain via disinhibition, that is, by
inhibiting “secondary cells,” which results in disinhibition of “primary cells,” considered to be …

The enhanced electrochemical activity of nanostructured materials is readily exploited in
energy devices, but their utility in scalable and human-compatible implantable neural interfaces …

Two broad hypotheses have been advanced to explain the clinical efficacy of deep brain
stimulation (DBS) in the subthalamic nucleus (STN) for treatment of Parkinson's disease. One is …

Despite similar behavioral hypersensitivity, acute and chronic pain have distinct neural bases.
We used intraplantar injection of complete Freund’s adjuvant to directly compare activity …

Opioids activate the descending antinociceptive pathway from the ventrolateral periaqueductal
gray (vlPAG) by both pre- and postsynaptic inhibition of tonically active GABAergic …

Despite ongoing advances in our understanding of local single-cellular and network-level
activity of neuronal populations in the human brain, extraordinarily little is known about their “…