Homologous recombination is a fundamental biological process. Biochemical understanding
of this process is most advanced for Escherichia coli. At least 25 gene products are …

Platelets release preformed mediators and generate eicosanoids that regulate acute hemostasis
and inflammation, but these anucleate cytoplasts are not thought to synthesize proteins …

Cyclooxygenase-2 (COX-2) expression is normally tightly regulated. However, constitutive
overexpression plays a key role in colon carcinogenesis. To understand the molecular nature …

The cyclooxygenase (COX)-2 enzyme is responsible for increased prostaglandin formation
in inflammatory states and is the major target of nonsteroidal anti-inflammatory drugs. …

Circulating human platelets lack nuclei, cannot synthesize mRNA, and are considered
incapable of regulated protein synthesis. We found that thrombin-activated, but not resting, …

The RecBCD enzyme is a multifunctional enzyme that is essential for homologous
recombination in E. coli. In vitro, the RecBCD enzyme degrades linear doublestranded DNA …

BACKGROUND & AIMS: During tumorigenesis, loss of rapid messenger RNA (mRNA)
decay allows for overexpression of cancer-associated genes. The RNA-binding proteins Hu …

The cyclooxygenase-2 (COX-2) enzyme catalyzes the rate-limiting step of prostaglandin
formation in inflammatory states, and COX-2 overexpression plays a key role in carcinogenesis. …

Commonly observed in colorectal cancer is the elevated expression of the prostaglandin (PG)
synthase COX-2. In normal intestinal epithelium, the COX-2 mRNA is targeted for rapid …

Adenylate‐ and uridylate‐rich element (ARE) motifs are cis‐acting elements present in the 3
′ untranslated region of mRNA transcripts that encode many inflammation‐ and cancer‐…