Background Neuropathic pain is a common and severely disabling state that affects millions
of people worldwide. Microglial activation in the spinal cord plays a critical role in the …

Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …

Paclitaxel-induced neuropathic pain (PINP) is refractory to currently used analgesics.
Previous studies show a pivotal role of oxidative stress in PINP. Because the nuclear factor …

Chronic pain is among the most disabling and costly disorders, with prevalence ranging
from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory …

Cancer-induced bone pain (CIBP) is a frequent complication in patients suffering from bone
metastases. Previous studies have demonstrated a pivotal role of reactive oxygen species (…

Ischemia-reperfusion (I/R) injury is accompanied with high morbidity and mortality and has
seriously negative social and economic influences. Unfortunately, few effective therapeutic …

Chronic pain remains an enormous health problem affecting approximatively 30% of the
world's population. Opioids as the first line analgesics often leads to undesirable side effects …

Background. Neuropathic pain is a debilitating disease with few effective treatments. Emerging
evidence indicates the involvement of mitochondrial dysfunction and oxidative stress in …

Chronic pain remains to be a clinical challenge due to insufficient therapeutic strategies.
Minocycline is a member of the tetracycline class of antibiotics, which has been used in clinic for …

Paclitaxel-induced neuropathic pain (PINP) is a dose-limiting side effect and is refractory to
widely used analgesic drugs. Previous studies have demonstrated a protective role of …