5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a
group of pro-inflammatory lipid mediators derived from arachidonic acid. Leukotriene …

5-Lipoxygenase (5-LOX) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid
mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX …

5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene (LT)
A 4 and 5-hydroperoxyeicosatetraenoic acid. LTA 4 can then be converted into LTB 4 by …

The acylphloroglucinol derivative hyperforin is the major lipophilic constituent in the herb
Hypericum perforatum (St. John’s wort). The aim of the present study was to investigate if …

… Moreover, binding sites for melatonin with K d values in the picomolar range have been …
), and a membrane receptor for melatonin with a K d -value of 0.063 nM has been cloned …

Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …

… Steinhilber … The authors could show that the increase in 5-LO mRNA during DMSO
induced differentiation of HL-60 cells is neither due to transcriptional activation of the gene …

In individuals with mammary carcinoma, the most relevant prognostic predictor of distant
organ metastasis and clinical outcome is the status of axillary lymph node metastasis. …

Changes in vitamin D serum levels have been associated with inflammatory diseases, such
as inflammatory bowel disease (IBD), rheumatoid arthritis, systemic lupus erythematosus, …

5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory
leukotrienes. This study showed that various forms of cell stress, such as chemical stress (sodium …