In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-Gl).
Its structure was determined by mass spectrometry and by direct comparison with a …

Two cannabinoid receptors have been identified to date; one is located predominantly in
the central nervous system (CB1), whereas the other is located exclusively in the periphery (…

Cannabinoids, including the endogenous ligand arachidonyl ethanolamide (anandamide),
elicit not only neurobehavioral but also cardiovascular effects. Two cannabinoid receptors, …

Although a receptor exists for cannabinoid drugs, it is uncertain which pharmacological
actions this receptor mediates. This structure-activity relationship investigation was initiated to …

Numerous cannabinoids have been synthesized that are extremely potent in all of the
behavioral assays conducted in our laboratory. An important feature in increasing potency has …

The arachidonic acid derivative anandamide (arachidonylethan-olamide) has been isolated
from porcine brain and has been shown to bind competitively to the cannabinoid receptor. …

… to 19% yield All of the indoles were evaluated in virro by measuring their ability to displace
[3Hl CP-55,940 (2) from its binding site in a membrane preparation as described by Compton …

The pharmacological effects of three stereoisomeric pairs of structurally novel cannabinoids
were tested after iv administration in mice for depression of spontaneous activity and the …

SR141716A has been described as a cannabinoid receptor antagonist. This study was
conducted to determine whether SR141716A was capable of antagonizing the pharmacological …

Six novel aminoalkylindole analogs, related structurally to the dual cyclooxygenase inhibitor
and nonopioid analgesic pravadoline, were evaluated in the mouse to determine whether …