The recent discovery of transporters in the intestinal mucosa and the canalicular membrane
has given new insights into the regulation of intestinal absorption as well as the biliary …

The cholesterol-lowering effect of phytosterols has been extensively studied, and consumption
of phytosterols is among the recommendations to lower LDL-cholesterol concentrations. …

Dietary plant sterols and stanols as present in our diet and in functional foods are well-known
for their inhibitory effects on intestinal cholesterol absorption, which translates into lower …

Recent epidemiological studies show a strong reduction in the incidence of Alzheimer's disease
in patients treated with cholesterol-lowering statins. Moreover, elevated Aβ42 levels and …

… In conclusion, 2 weeks of treatment with ezetimibe at 10 mg/d produced a 54% inhibition
of cholesterol absorption in mildly to moderately hypercholesterolemic subjects. This was …

Background The effect of increasing the intake of dietary fiber on glycemic control in patients
with type 2 diabetes mellitus is controversial. Methods In a randomized, crossover study, we …

… brain contains about 80% of the 24S-hydroxycholesterol in the human body and that there
is a net flux of this steroid from the brain into the circulation (Lütjohann, D. et al. 1996. Proc. …

Cholesterol and other sterols exit the body primarily by secretion into bile. In patients with
sitosterolemia, mutations in either of two ATP-binding cassette (ABC) half-transporters, ABCG5 …

We have investigated whether side chain-hydroxylated cholesterol species are important for
elimination of cholesterol from the brain. Plasma concentrations of 24-hydroxycholesterol (…

Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary
tangles, and neuronal cell loss associated with membrane cholesterol release. 24S-…