Osteoclast differentiation and activation
WJ Boyle, WS Simonet, DL Lacey - Nature, 2003 - nature.com
… d, Scanning electron micrograph of human osteoclasts generated in vitro on cortical bone
slices from CSF-1- and RANKL-treated peripheral blood mononuclear cells. Red propellers, …
slices from CSF-1- and RANKL-treated peripheral blood mononuclear cells. Red propellers, …
The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
…, S Khosla, CR Dunstan, DL Lacey… - Journal of bone and …, 2000 - academic.oup.com
Although multiple hormones and cytokines regulate various aspects of osteoclast formation,
the final two effectors are osteoprotegerin ligand (OPG‐L)/osteoclast differentiation factor (…
the final two effectors are osteoprotegerin ligand (OPG‐L)/osteoclast differentiation factor (…
Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab
DL Lacey, WJ Boyle, WS Simonet… - Nature reviews Drug …, 2012 - nature.com
Bone is a complex tissue that provides mechanical support for muscles and joints, protection
for vital organs, a mineral reservoir that is essential for calcium homeostasis, and the …
for vital organs, a mineral reservoir that is essential for calcium homeostasis, and the …
[HTML][HTML] Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
DL Lacey, E Timms, HL Tan, MJ Kelley, CR Dunstan… - cell, 1998 - cell.com
… for both) of TRAP-stained sections of osteoclasts on bone from control (D) and OPGL (E)
injected animals. The calibration bar represents 25 μm and applies to both (D) and (E). …
injected animals. The calibration bar represents 25 μm and applies to both (D) and (E). …
[HTML][HTML] Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
WS Simonet, DL Lacey, CR Dunstan, M Kelley… - cell, 1997 - cell.com
A novel secreted glycoprotein that regulates bone resorption has been identified. The protein,
termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, …
termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, …
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
…, A Itie, W Khoo, A Wakeham, CR Dunstan, DL Lacey… - Nature, 1999 - nature.com
… d, Wild-type allogeneic BALB/c T cells (H–2 d/d ) were activated for 4 days with different
numbers (x-axis) of splenic CD11c + CD80 + dendritic cells (DCs) (H–2 b/b ) isolated from opgl +…
numbers (x-axis) of splenic CD11c + CD80 + dendritic cells (DCs) (H–2 b/b ) isolated from opgl +…
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
…, S Scully, HL Tan, W Xu, DL Lacey… - Genes & …, 1998 - genesdev.cshlp.org
Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study
the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent …
the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent …
Dickkopf-1 is a master regulator of joint remodeling
…, D van der Heide, R Landewe, D Lacey… - Nature medicine, 2007 - nature.com
Degenerative and inflammatory joint diseases lead to a destruction of the joint architecture.
Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid …
Whereas degenerative osteoarthritis results in the formation of new bone, rheumatoid …
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
Bone remodelling and bone loss are controlled by a balance between the tumour necrosis
factor family molecule osteoprotegerin ligand (OPGL) and its decoy receptor osteoprotegerin (…
factor family molecule osteoprotegerin ligand (OPGL) and its decoy receptor osteoprotegerin (…
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
H Hsu, DL Lacey, CR Dunstan… - Proceedings of the …, 1999 - National Acad Sciences
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation
and activation has been identified via genomic analysis of a primary osteoclast precursor cell …
and activation has been identified via genomic analysis of a primary osteoclast precursor cell …