… Dennis Felsing† dennis.felsing@student.kit.edu Sarah Grebing† sarah.grebing@kit.edu …
Hähnle, and D. Sands. A theorem proving approach to analysis of secure information flow. …

The dopamine D1 receptor (D1R) is essential for neurotransmission in various brain pathways
where it modulates key functions including voluntary movement, memory, attention and …

… Given the poor affinity of (+)-5-FPT at D 2 receptors and our observations that (+)-5-FPT (5.6
mg/kg) did not significantly decrease hyperlocomotion elicited by amphetamine or affect …

Opioid use by women during pregnancy has risen dramatically since 2004, accompanied by
a striking increase in the prevalence of neonatal opioid withdrawal syndrome (NOWS) and …

… ligand affinity, by statistically comparing receptor affinity values (K d ). Data from saturation
binding isotherms are presented as B MAX and K d values (mean ± SEM), as computed by …

Noncatechol heterocycles have recently been discovered as potent and selective G protein
biased dopamine 1 receptor (D1R) agonists with superior pharmacokinetic properties. To …

The G protein-coupled receptor 52 (GPR52) is an orphan receptor that is selectively
expressed in the striatum and regulates various brain functions through activation of cAMP-…

Development of 5-HT 2C agonists for treatment of neuropsychiatric disorders, including
psychoses, substance abuse, and obesity, has been fraught with difficulties, because the vast …

… K d and K i values report ligand affinities, or how tight a ligand binds to a target, but they are
obtained through different experimental methods; though K d and K i values of a ligand are …

… The 5-substituted-2-tetralone analogs 7a-d and 7h-t underwent reductive amination 22 with
dimethylamine to give the racemic 5-SAT analogs 8a-d and 8h-t. Preparative chiral HPLC (…