User profiles for D. Clive Williams
Clive Williamsprofessor, trinity college dublin Verified email at tcd.ie Cited by 7200 |
The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications
Ruthenium(II) [Ru(II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years, there …
since work began exploring their supramolecular interactions with DNA. In recent years, there …
The serotonin transporter: a primary target for antidepressant drugs
P Schloss, DC Williams - Journal of psychopharmacology, 1998 - journals.sagepub.com
The serotoninergic system is known to modulate mood, emotion, sleep and appetite and
thus is implicated in the control of numerous behavioural and physiological functions. …
thus is implicated in the control of numerous behavioural and physiological functions. …
Membrane cholesterol modulates serotonin transporter activity
SM Scanlon, DC Williams, P Schloss - Biochemistry, 2001 - ACS Publications
The synaptic actions of the neurotransmitter serotonin are terminated by a selective high-affinity
reuptake mediated by the serotonin transporter (SERT). To gain insight into the …
reuptake mediated by the serotonin transporter (SERT). To gain insight into the …
Luminescent ruthenium (II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents
…, KN Orange, SM Cloonan, DC Williams… - Journal of the …, 2011 - ACS Publications
The synthesis and photophysical and biological investigation of Ru(II)-polypyridyl stabilized
water-soluble, luminescent gold nanoparticles (AuNPs) are described. These structures bind …
water-soluble, luminescent gold nanoparticles (AuNPs) are described. These structures bind …
[HTML][HTML] Comparison of seven different heterologous protein expression systems for the production of the serotonin transporter
…, M Boorsma, F Magnani, Y Vallis, DC Williams - … et Biophysica Acta (BBA …, 2003 - Elsevier
The rat serotonin transporter (rSERT) is an N-glycosylated integral membrane protein with
12 transmembrane regions; the N-glycans improve the ability of the SERT polypeptide chain …
12 transmembrane regions; the N-glycans improve the ability of the SERT polypeptide chain …
Detailed biological profiling of a photoactivated and apoptosis inducing pdppz ruthenium (II) polypyridyl complex in cancer cells
Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT)
agents. However, a lack of detailed understanding of their mode of action in cells poses a …
agents. However, a lack of detailed understanding of their mode of action in cells poses a …
Glycosidase activated release of fluorescent 1, 8-naphthalimide probes for tumor cell imaging from glycosylated 'pro-probes'
…, MO Senge, EB Veale, DC Williams… - Chemical …, 2016 - pubs.rsc.org
Glycosylated 4-amino-1,8-naphthalimide derivatives possess a native glycosidic linkage that
can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide …
can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide …
Synthesis, spectroscopic and biological studies of a fluorescent Pt (II)(terpy) based 1, 8-naphthalimide conjugate as a DNA targeting agent
…, SA Bright, JE O'Brien, DC Williams… - Chemical …, 2013 - pubs.rsc.org
… P/D for 1 as well as for 3 and [Pt(terpy)(4-picoline)]2+. … P/D for 1 as well as for 3 and [Pt(terpy)(4-picoline)]
2+ . … blue shift in the λ max , at P/D = 0.6) while further additions of DNA cause …
2+ . … blue shift in the λ max , at P/D = 0.6) while further additions of DNA cause …
Luminescent lanthanide cyclen-based enzymatic assay capable of diagnosing the onset of catheter-associated urinary tract infections both in solution and within …
…, SA Bright, CP McCoy, DC Williams… - Journal of the …, 2017 - ACS Publications
Herein we present a supramolecular (delayed luminescent) Eu(III)-based pH-responsive
probe/sensor with the ability to detect the urease-mediated hydrolysis of urea in aqueous …
probe/sensor with the ability to detect the urease-mediated hydrolysis of urea in aqueous …
Multiple forms and locations for the peripheral-type benzodiazepine receptor
MJ Woods, DC Williams - Biochemical pharmacology, 1996 - Elsevier
The pharmacological effects of benzodiazepines are mediated through a class of recognition
sites associated with the neuronal γ-aminobutyric acid A (GABA A ) receptor. A second …
sites associated with the neuronal γ-aminobutyric acid A (GABA A ) receptor. A second …