Rationale Kappa opioid receptors (KORs) have been implicated in depressive-like states
associated with chronic administration of drugs of abuse and stress. Although KOR agonists …

Early life stress exposure (ELS) yields risk for psychiatric disorders that might occur though
a population-specific mechanism that impacts prefrontal cortical development. Sex …

The development of diet-induced obesity (DIO) can potently alter multiple aspects of dopamine
signaling, including dopamine transporter (DAT) expression and dopamine reuptake. …

… form at the Society for Neuroscience annual meeting (Potter et al., Society for Neuroscience
2008… David Potter, and Dr. Elena Chartoff report no biomedical financial interests or potential …

Dependence is a hallmark feature of opiate addiction and is defined by the emergence of
somatic and affective withdrawal signs. The nucleus accumbens (NAc) integrates …

Prescription opioid abuse is an increasing public health concern in the USA. A vaccine
comprising a hapten (OXY) conjugated to the carrier protein keyhole limpet hemocyanin (OXY-…

Rationale Mood disorders can be triggered by stress and are characterized by deficits in
reward processing, including disrupted reward learning (the ability to modulate behavior …

Rationale Intermittent social defeat stress can induce neuroadaptations that promote
compulsive drug taking. Within the mesocorticolimbic circuit, repeated cocaine administration …

Background: Intraplantar administration of complete Freund's adjuvant (CFA) and formalin
are two noxious stimuli commonly used to produce sustained pain-related behaviors in …

Several preclinical studies indicate that selective κ-opioid receptor (KOR) antagonists have
antidepressant-like effects, whereas KOR agonists have opposite effects, suggesting that …