Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are effective drugs for the treatment
of several neuropsychiatric disorders associated with reduced serotonergic function. …

The 5-HT 2A/2C agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI)
stimulates hypothalamic neurons to increase the secretion of several hormones. This study …

The aim of the present study was to investigate the anxiolytic effects of long-term treatment
with fluoxetine in rats. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are …

The present study investigated whether estrogen would desensitize hypothalamic serotonin
1A (5-HT 1A ) receptors by examining the neuroendocrine response to 8-OH-DPAT, a 5-HT …

The present studies examined the dose-response relationship of fluoxetine-induced
desensitization of hypothalamic postsynaptic 5-HT 1A receptors, as measured from the reduced …

Using in situ hybridization and immunoblot analysis, the present studies identified G z mRNA
and G z -protein in the hypothalamic paraventricular nucleus. The role of G z -proteins in …

Long-term exposure to fluoxetine produces a desensitization of hypothalamic postsynaptic 5-hydroxytryptamine
(5-HT) 1A receptors, indicated by a substantial inhibition of the 5-HT 1A …

The circadian rhythm of core body temperature (Tb) was examined in two mouse lines
bidirectionally selected for nest-building behavior (small (SNB) and big nest-builders (BNB)). This …

Desensitization of 5-HT 1A receptors could be involved in the long-term therapeutic effect of
anxiolytic and antidepressant drugs. Pretreatment of rats with the 5-HT 2A/2C agonist DOI …

Chronic cocaine exposure during critical periods of development induces short- and long-term
effects. During the pubertal period, the hypothalamic–pituitary–gonadal (HPG) axis …