Synthetic oligonucleotides: the development of antisense therapeutics

DK Monteith, AA Levin - Toxicologic pathology, 1999 - journals.sagepub.com
Antisense therapeutics using synthetic oligodeoxynucleotides (ODNs) are currently being
evaluated in clinical trials for cancer, inflammation, and viral diseases. These macromolecules …

In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration

MJ Graham, ST Crooke, DK Monteith, SR Cooper… - … of Pharmacology and …, 1998 - ASPET
In the rat, the liver represents a major site of phosphorothioate oligodeoxynucleotide deposition
after iv administration. For this reason, we examined the intracellular fate of ISIS 1082, a …

Tissue disposition of 2′‐O‐(2‐methoxy) ethyl modified antisense oligonucleotides in monkeys

ZY Rosie, RS Geary, DK Monteith, J Matson… - Journal of …, 2004 - Elsevier
This study examined the plasma pharmacokinetics, tissue distribution, and metabolism of
three second generation antisense oligonucleotides in monkeys. Three groups of monkeys …

Immune stimulation-a class effect of phosphorothioate oligodeoxynucleotides in rodents

SP Henry, DK Monteith, CF Bennett… - Anti-cancer drug …, 1997 - ingentaconnect.com
… Correspondence to: DK MonteithDK MONTEITH et al. … DK MONTEITH et al. …

Degradation and inactivation of antitumor drugs

JA Benvenuto, TH Connor, DK Monteith… - Journal of …, 1993 - Elsevier
Chemical methods for the degradation of 11 anti neoplastic drugs [etoposide, teniposide,
bleomycin, mitomycin C, cisplatin, cis- dichloro-frans-dihydroxy-bis(isopropylamlne) platinum …

Evaluation of the renal effects of an antisense phosphorothioate oligodeoxynucleotide in monkeys

DK Monteith, MJ Horner, NA Gillett… - Toxicologic …, 1999 - journals.sagepub.com
Antisense phosphorothioate oligodeoxynucleotides are therapeutic agents that provide
target specificity resulting from Watson-Crick base pairing. However, there are nonspecific …

Relationships between genomic, cell cycle, and mutagenic responses of TK6 cells exposed to DNA damaging chemicals

…, L Flick, JL Altizer, JT Deahl, DK Monteith… - Mutation Research …, 2005 - Elsevier
Genotoxic stress causes a variety of cellular and molecular responses in mammalian cells,
including cell cycle arrest, DNA repair, and apoptosis. These responses result from the …

Genotoxicity of organic chemicals frequently found in the air of mobile homes

TH Connor, JC Theiss, HA Hanna, DK Monteith… - Toxicology letters, 1985 - Elsevier
MONTEITH … 5 DK Monteith, TH Stock and W. Seifert, Sources and concentrations … 7
DA Sterling, TH Stock and DK Monteith, Factors influencing formaldehyde …

In vitro assays and biomarkers for drug-induced phospholipidosis

DK Monteith, RE Morgan, B Halstead - Expert opinion on drug …, 2006 - Taylor & Francis
Drug-induced phospholipidosis is the cytoplasmic accumulation of phospholipids as a result
of xenobiotic exposure. This accumulation results in a unique histological effect in cells …

Comparison of the microgel electrophoresis assay and other assays for genotoxicity in the detection of DNA damage

DK Monteith, J Vanstone - Mutation Research/Genetic Toxicology, 1995 - Elsevier
Genotoxic agents can be detected by measuring DNA damage which result in the migration
of DNA from single cells in agarose, using an electrophoretic field under alkaline conditions. …