User profiles for D. K. CHANG

David K. Chang

Professor of Surgical Oncology, University of Glasgow
Verified email at glasgow.ac.uk
Cited by 23380

Molecular subtypes of pancreatic cancer

EA Collisson, P Bailey, DK Chang… - Nature reviews …, 2019 - nature.com
Cancers that appear morphologically similar often have dramatically different clinical features,
respond variably to therapy and have a range of outcomes. Compelling evidence now …

Interrogating open issues in cancer precision medicine with patient-derived xenografts

…, A Bruna, E Budinská, C Caldas, DK Chang… - Nature Reviews …, 2017 - nature.com
Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new
treatments and biomarkers in oncology. PDX models are used to address clinically relevant …

[HTML][HTML] Colorectal cancer in inflammatory bowel disease: the risk, pathogenesis, prevention and diagnosis

ER Kim, DK Chang - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Patients with inflammatory bowel disease (IBD) are at increased risk for developing
colorectal cancer (CRC), although the overall incidence of IBD-associated CRC has been …

Genomic analyses identify molecular subtypes of pancreatic cancer

P Bailey, DK Chang, K Nones, AL Johns, AM Patch… - Nature, 2016 - nature.com
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

…, DK Miller, PJ Wilson, AM Patch, J Wu, DK Chang… - Nature, 2012 - nature.com
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

Whole genomes redefine the mutational landscape of pancreatic cancer

N Waddell, M Pajic, AM Patch, DK Chang, KS Kassahn… - Nature, 2015 - nature.com
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden.
We performed whole-genome sequencing and copy number variation (CNV) analysis of …

Whole-genome landscape of pancreatic neuroendocrine tumours

A Scarpa, DK Chang, K Nones, V Corbo, AM Patch… - Nature, 2017 - nature.com
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

[PDF][PDF] CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma

…, N Jamieson, CR Carter, F Balkwill, DK Chang… - Cancer cell, 2016 - cell.com
CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive
properties. Here we show that CXCR2 signaling is upregulated in human pancreatic cancer, …

Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986–2005: a KASID study

…, JY Park, HY Kim, YH Kim, DK Chang… - Inflammatory bowel …, 2008 - academic.oup.com
Background Crohn's disease (CD) and ulcerative colitis (UC) are considered rare diseases
in developing countries. We have evaluated the incidence and prevalence of CD and UC …

Proline inhibits aggregation during protein refolding

…, VD Trivedi, SL Wang, KC Hwang, DK Chang… - Protein …, 2000 - cambridge.org
The in vitro refolding of hen egg-white lysozyme is studied in the presence of various
osmolytes. Proline is found to prevent aggregation during protein refolding. However, other …