During the first decade of the 21st century it is unlikely that the pages of specialist
pharmacology journals will overflow with papers reporting studies on the isolated uterus. This …

Atrazine (ATR) is a pesticide used widely throughout North America. Although not directly
estrogenic, ATR treatment has been shown to increase aromatase activity in tumor cell lines. …

An investigation of the constituents in heartwood and resin of Prunus avium is reported. A
mini-library of structurally diverse flavanones and flavones was screened for human …

Dietary phytoestrogens have been reported to inhibit aromatase activity in placental
microsomes, but the effects in the human endometrium are unknown. Aromatase, the rate-limiting …

… Together with our previous work showing potent effects of both PG12 and thromboxane A2
mimetics on the lower uterine segment at term in vitro (Dyd and Crankshaw H988), this study …

A library of natural and semi-synthetic Amaryllidaceae alkaloids was screened for cytochrome
P450 3A4 (CYP3A4) inhibitory activity. Of the crinane, lycorane and galanthamine …

Background. The use of herbal medicines by pregnant women is on the rise. However, there
is limited information regarding the safety of these compounds during pregnancy. Therefore…

Isoprostanes are generated nonenzymatically during free radical-mediated lipid peroxidation,
and are used clinically and experimentally as markers of oxidative stress. However, their …

There is controversy as to whether maternal age exerts an influence on the contractility of
human myometrium in pregnancy. The aim of this study was to examine a series of functional …

Isoprostanes are members of a family of prostaglandin isomers that are produced by free
radical-catalysed mechanisms. They have become well-recognized indicators of oxidant-…