A simple, high-yielding synthesis of 2,4,5-trisubstituted imidazoles from 1,2-diketones and
aldehydes in the presence of NH 4 OAc is described. Under microwave irradiation, alkyl-, aryl-…

RIP1 regulates necroptosis and inflammation and may play an important role in contributing
to a variety of human pathologies, including immune-mediated inflammatory diseases. Small…

We found that 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) is a potent
and selective positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (…

Functionalized quinoxalines and heterocyclic pyrazines are expediently prepared in excellent
yields (69–99%) from common 1,2-diketone intermediates under microwave irradiation. In …

This report describes the discovery of the first centrally active allosteric modulators of the
metabotropic glutamate receptor subtype 5 (mGluR5). Appropriately substituted N-(1,3-diphenyl…

We found that N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
(CPPHA), is a potent and selective positive allosteric modulator of the …

DNA-encoded small-molecule library technology has recently emerged as a new paradigm
for identifying ligands against drug targets. To date, this technology has been used with …

… Wisnoski , Craig W. Lindsley … Leister, WH; Strauss, KA; Wisnoski, DD; Zhao, Z.; Lindsley,
CW J. Comb. Chem., submitted. … H NMR (300 MHz, CDCl 3 ): δ 7.56 (m, 4H), 7.36 (m, 6H) …

A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening
campaign as novel, potent small molecule agonists of the human TGR5 G-protein coupled …

RIP1 kinase regulates necroptosis and inflammation and may play an important role in
contributing to a variety of human pathologies, including inflammatory and neurological diseases. …