There is increasing evidence that nitric oxide (NO) is an important molecular messenger
involved in a wide variety of biological processes. Recent data suggest that NO is also involved …

The cerebral vasculature is a target tissue for sex steroid hormones. Estrogens, androgens,
and progestins all influence the function and pathophysiology of the cerebral circulation. …

This review covers the pathogenesis of ischemic stroke and future directions regarding
therapeutic options after injury. Ischemic stroke is a devastating disease process affecting …

Background and Purpose— Endothelial nitric oxide synthase (eNOS) activity is decreased
after subarachnoid hemorrhage (SAH). Simvastatin increases eNOS activity. We …

Neuroprotection against cerebral ischemia can be realized if the brain is preconditioned by
previous exposure to a brief period of sublethal ischemia. The present study was undertaken …

Background and Purpose—Estrogen-related neuroprotection in association with animal
models of transient forebrain and focal ischemia has been documented in several recent reports…

The nitric oxide synthase (NOS) inhibitors, nitro-L-arginine, its methyl ester, and N-monomethyl-L-arginine,
have been shown to attenuate resting CBF and hypercapnia-induced …

The vasodilating capability of cerebral vessels is vital to brain survival. There are multiple
mechanisms participating in the regulation of cerebral vascular smooth muscle relaxation. The …

While the influence of caffeine on the regulation of brain perfusion has been the subject of
multiple publications, the mechanisms involved in that regulation remain unclear. To some …

THE effects of chronic 17β-estradiol (E 2) depletion, via ovariectomy (OVX), and its repletion,
on cortical cerebral blood flow (CBF) and EEG activities during forebrain ischemia, as well …