Cocaine addiction is thought to involve persistent neurobiological changes that facilitate
relapse to drug use despite efforts to abstain. But the propensity for relapse may be reduced by …

Recent cannabinoid research has a primary focus on developing therapeutics against human
diseases. Many studies on cannabinoids indicate important progress for protection against …

The endocannabinoid system has been suggested to elicit signals that defend against
several disease states including excitotoxic brain damage. Besides direct activation with CB 1 …

Endocannabinoids are released in response to pathogenic insults, and inhibitors of
endocannabinoid inactivation enhance such on-demand responses that promote cellular protection. …

… The precursor mass tolerance was set to 50 ppm for the MS 1 , and the fragment mass
tolerance to 1.5 Da with up to three missed cleavages allowed. Final protein lists were filtered to …

The endocannabinoid system's biological significance continues to grow as novel endocannabinoid
metabolites are discovered. Accordingly, a myopic view of the system that focuses …

Individual differences in locomotor responses to novelty and psychostimulants, and sensitization
following repeated drug exposure, predict increased sensitivity to the reinforcing effects …

The endogenous cannabinoid system has revealed potential avenues to treat many disease
states. Medicinal indications of cannabinoid drugs including compounds that result in …

Synaptic pathology is associated with protein accumulation events, and is thought by many
to be the best correlate of cognitive impairment in normal aging and different types of …

Advances in the understanding of the endogenous cannabinoid system have led to several
therapeutic indications for new classes of compounds that enhance cannabinergic responses…