This investigation describes the expression and interindividual variability in transcript levels
of multiple drug efflux systems in the human jejunum and compares the expression profiles …

Background & Aims: Rifampicin (RIFA) and ursodeoxycholic acid (UDCA) improve symptoms
and biochemical markers of liver injury in cholestatic liver diseases by largely unknown …

The contribution of hereditary and environmental factors to the pathogenesis of symptomatic
gallstone disease is still unclear. We estimated the relative importance of genetic and …

Background & Aims Bile acids (BAs) are major regulators of hepatic BA and lipid metabolism
but their mechanisms of action in non-alcoholic fatty liver disease (NAFLD) are still poorly …

The major cholesterol oxidation products in the human circulation are 27-hydroxycholesterol,
24-hydroxycholesterol, and 7α-hydroxycholesterol. These oxysterols are formed from …

Background— Two acyl-coenzyme A:cholesterol acyltransferase (ACAT) genes, ACAT1 and
ACAT2, have been identified that encode 2 proteins responsible for intracellular cholesterol …

Fibrates are a group of hypolipidemic agents that efficiently lower serum triglyceride levels
by affecting the expression of many genes involved in lipid metabolism. These effects are …

The brain is the almost exclusive site of formation of 24S-hydroxycholesterol in man, and there
is a continuous flux of this oxysterol across the blood-brain barrier into the circulation. The …

Cholesterol supersaturation of bile is one prerequisite for gallstone formation. In the present
study of Chinese patients with gallstones, we investigated whether this phenomenon was …

The biosynthesis of bile acids by primary cultures of normal human hepatocytes has been
investigated. A general and sensitive method for the isolation and analysis of sterols and bile …