Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis

P Keul, S Lucke, K von Wnuck Lipinski, C Bode… - Circulation …, 2011 - Am Heart Assoc
Rationale: The role of sphingosine-1-phosphate (S1P) and its receptors in the pathogenesis
of atherosclerosis has not been investigated. Objective: We hypothesized that the S1P …

Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease

…, Ş Elbasan, P Keul, M Elter-Schulz, C Bode… - Basic research in …, 2010 - Springer
High-density lipoproteins (HDL) are the major plasma carriers for sphingosine 1-phosphate (S1P)
in healthy individuals, but their S1P content is unknown for patients with coronary …

Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1‐phosphate

C Bode, SC Sensken, U Peest, G Beutel… - Journal of cellular …, 2010 - Wiley Online Library
Sphingosine 1‐phosphate (S1P) in blood is phosphorylated, stored, and transported by red
blood cells (RBC). Release of S1P from RBC into plasma is a regulated process that does …

[HTML][HTML] Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1

S Vettorazzi, C Bode, L Dejager, L Frappart… - Nature …, 2015 - nature.com
Acute lung injury (ALI) is a severe inflammatory disease for which no specific treatment
exists. As glucocorticoids have potent immunosuppressive effects, their application in ALI is …

Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia

SC Sensken, C Bode, M Nagarajan… - The Journal of …, 2010 - journals.aai.org
Sphingosine kinases (SKs) 1 and 2 produce high concentrations of sphingosine 1-phosphate
(S1P) in blood and lymph. In contrast, S1P concentrations in lymphoid tissues are kept low …

Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice

C Weber, A Krueger, A Münk, C Bode… - The Journal of …, 2009 - journals.aai.org
Circulation of lymphocytes through peripheral lymphoid tissues as well as progenitor entry
into the thymus and its output of mature T cells are critical for normal immune function. Egress …

Quantification of sphingosine-1-phosphate and related sphingolipids by liquid chromatography coupled to tandem mass spectrometry

C Bode, MH Gräler - Sphingosine-1-Phosphate: Methods and Protocols, 2012 - Springer
Liquid chromatography coupled to tandem mass spectrometry has evolved as the method of
choice for the detection of sphingolipid metabolites due to its high sensitivity and superior …

Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy

SC Sensken, C Bode, MH Gräler - Journal of Pharmacology and …, 2009 - ASPET
The immunomodulator fingolimod (FTY720) induces lymphopenia by inhibiting lymphocyte
egress from thymus and secondary lymphoid organs (SLOs). It is phosphorylated mainly by …

Local inactivation of sphingosine 1-phosphate in lymph nodes induces lymphopenia

SC Sensken, M Nagarajan, C Bode… - The Journal of …, 2011 - journals.aai.org
Sphingosine 1-phosphate (S1P) initiates T and B cell exit from lymphoid tissues by
activating the S1P 1 receptor on lymphocytes. To define the mechanistic details of this ligand–…

Immune regulation by sphingosine 1-phosphate and its receptors

C Bode, MH Gräler - Archivum immunologiae et therapiae experimentalis, 2012 - Springer
It is well established that the lysophospholipid and signalling molecule sphingosine 1-phosphate
(S1P) has many important functions in immune surveillance. S1P is produced from …