Phonetic feature encoding in human superior temporal gyrus

N Mesgarani, C Cheung, K Johnson, EF Chang - Science, 2014 - science.org
During speech perception, linguistic elements such as consonants and vowels are extracted
from a complex acoustic speech signal. The superior temporal gyrus (STG) participates in …

The auditory representation of speech sounds in human motor cortex

C Cheung, LS Hamilton, K Johnson, EF Chang - elife, 2016 - elifesciences.org
10.7554/eLife.12577.001 In humans, listening to speech evokes neural responses in the
motor cortex. This has been controversially interpreted as evidence that speech sounds are …

Helping youth in care succeed: Influence of caregiver involvement on academic achievement

C Cheung, K Lwin, JM Jenkins - Children and Youth Services Review, 2012 - Elsevier
The current study examined the influence of the placement on academic outcomes in youth
receiving out-of-home care. A two-level multilevel model was used to partition variance in …

The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

C Cheung, AM Yu, JM Ward, KW Krausz… - Drug metabolism and …, 2005 - ASPET
The cytochrome P450 (P450) CYP2E1 enzyme metabolizes and activates a wide array of
toxicological substrates, including alcohols, the widely used analgesic acetaminophen, …

The PPARα-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPARα

Q Yang, T Nagano, Y Shah, C Cheung… - Toxicological …, 2008 - academic.oup.com
To determine the impact of the species difference between rodents and humans in response
to peroxisome proliferators (PPs) mediated by peroxisome proliferator–activated receptor (…

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

CMJ Hu, L Zhang, S Aryal, C Cheung… - Proceedings of the …, 2011 - National Acad Sciences
Efforts to extend nanoparticle residence time in vivo have inspired many strategies in particle
surface modifications to bypass macrophage uptake and systemic clearance. Here we …

Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment

C Cheung, FJ Gonzalez - Journal of Pharmacology and Experimental …, 2008 - ASPET
Cytochrome P450s (P450s) are important enzymes involved in the metabolism of xenobiotics,
particularly clinically used drugs, and are also responsible for metabolic activation of …

Differential Metabolism of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Mice Humanized for CYP1A1 and CYP1A2

C Cheung, X Ma, KW Krausz, S Kimura… - Chemical research in …, 2005 - ACS Publications
The procarcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most
abundant heterocyclic amine formed during the cooking of foods. Metabolism of PhIP by …

Peroxisome proliferator-activated receptor-α and liver cancer: where do we stand?

JM Peters, C Cheung, FJ Gonzalez - Journal of molecular medicine, 2005 - Springer
The peroxisome proliferator-activated receptor-α (PPARα), first identified in 1990 as a member
of the nuclear receptor superfamily, has a central role in the regulation of numerous target …

Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice

C Cheung, AM Yu, CS Chen, KW Krausz… - … of Pharmacology and …, 2006 - ASPET
The impact of age and sex on the expression of hepatic cytochrome P450 3A4 (CYP3A4)
was recently determined in a transgenic mouse line carrying the human CYP3A4 gene. To …