Histopathologic changes and SARS-CoV-2 immunostaining in the lung of a patient with COVID-19

H Zhang, P Zhou, Y Wei, H Yue, Y Wang… - Annals of internal …, 2020 - acpjournals.org
Background: Although many studies have demonstrated the epidemiologic characteristics of
SARS-CoV-2 disease (COVID-19), details of pathologic changes in the lung are still lacking…

A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes

…, W Zheng, S Purohit, RH Podolsky, A Muir, J Wang… - Nature …, 2004 - nature.com
Previous studies have suggested more than 20 genetic intervals that are associated with
susceptibility to type 1 diabetes (T1D) 1 , 2 , but identification of specific genes has been …

[HTML][HTML] Macrophages: friend or foe in idiopathic pulmonary fibrosis?

L Zhang, Y Wang, G Wu, W Xiong, W Gu, CY Wang - Respiratory research, 2018 - Springer
Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial lung
disease of unknown etiology. Over the past decade, macrophage has been recognized to …

Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China

…, Y Wang, Z Wang, X Chen, F Xu, F Wang… - The Journal of …, 2008 - jrheum.org
Objective To demonstrate the prevalence of hyperuricemia and gout associated with dietary
and lifestyle changes and evaluate the implication of metabolic disorders to the …

MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program

Y Wang, L Zhang, GR Wu, Q Zhou, H Yue, LZ Rao… - Science …, 2021 - science.org
Despite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still
remain poorly understood. Here, we demonstrated that lungs originating from different types of …

[HTML][HTML] Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria

J Wang, Q Wei, CY Wang, WD Hill, DC Hess… - Journal of Biological …, 2004 - ASBMB
Robust neuroprotective effects have been shown for minocycline. Whether it also protects
nonneuronal cells or tissues is unknown. More importantly, the mechanisms of minocylcine …

[HTML][HTML] Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling

…, L Zhang, YH Wang, Z Gao, Y Wang, X Wang… - Nature …, 2022 - nature.com
Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with
obesity are characterized by the excessive plasma kynurenine (Kyn). However, the primary …

[HTML][HTML] Chop deficiency protects mice against bleomycin-induced pulmonary fibrosis by attenuating M2 macrophage production

Y Yao, Y Wang, Z Zhang, L He, J Zhu, M Zhang, X He… - Molecular Therapy, 2016 - cell.com
C/EBP homologous protein (Chop) has been shown to have altered expression in patients
with idiopathic pulmonary fibrosis (IPF), but its exact role in IPF pathoaetiology has not been …

Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity

M Jiang, X Yi, S Hsu, CY Wang… - American Journal of …, 2004 - journals.physiology.org
Tubular damage by cisplatin leads to acute renal failure, which limits its use in cancer therapy.
In tubular cells, a primary target for cisplatin is presumably the genomic DNA. However, …

Obesity predisposes to the risk of higher mortality in young COVID‐19 patients

…, F Wang, G Li, K Liu, R Du, CY Wang… - Journal of medical …, 2020 - Wiley Online Library
Although emerging data demonstrated mortality of young COVID‐19 patients, no data have
reported the risk factors of mortality for these young patients, and whether obesity is a risk for …