Histopathologic changes and SARS-CoV-2 immunostaining in the lung of a patient with COVID-19
H Zhang, P Zhou, Y Wei, H Yue, Y Wang… - Annals of internal …, 2020 - acpjournals.org
Background: Although many studies have demonstrated the epidemiologic characteristics of
SARS-CoV-2 disease (COVID-19), details of pathologic changes in the lung are still lacking…
SARS-CoV-2 disease (COVID-19), details of pathologic changes in the lung are still lacking…
A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes
…, W Zheng, S Purohit, RH Podolsky, A Muir, J Wang… - Nature …, 2004 - nature.com
Previous studies have suggested more than 20 genetic intervals that are associated with
susceptibility to type 1 diabetes (T1D) 1 , 2 , but identification of specific genes has been …
susceptibility to type 1 diabetes (T1D) 1 , 2 , but identification of specific genes has been …
[HTML][HTML] Macrophages: friend or foe in idiopathic pulmonary fibrosis?
L Zhang, Y Wang, G Wu, W Xiong, W Gu, CY Wang - Respiratory research, 2018 - Springer
Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial lung
disease of unknown etiology. Over the past decade, macrophage has been recognized to …
disease of unknown etiology. Over the past decade, macrophage has been recognized to …
Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China
…, Y Wang, Z Wang, X Chen, F Xu, F Wang… - The Journal of …, 2008 - jrheum.org
Objective To demonstrate the prevalence of hyperuricemia and gout associated with dietary
and lifestyle changes and evaluate the implication of metabolic disorders to the …
and lifestyle changes and evaluate the implication of metabolic disorders to the …
MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program
Y Wang, L Zhang, GR Wu, Q Zhou, H Yue, LZ Rao… - Science …, 2021 - science.org
Despite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still
remain poorly understood. Here, we demonstrated that lungs originating from different types of …
remain poorly understood. Here, we demonstrated that lungs originating from different types of …
[HTML][HTML] Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria
Robust neuroprotective effects have been shown for minocycline. Whether it also protects
nonneuronal cells or tissues is unknown. More importantly, the mechanisms of minocylcine …
nonneuronal cells or tissues is unknown. More importantly, the mechanisms of minocylcine …
[HTML][HTML] Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling
…, L Zhang, YH Wang, Z Gao, Y Wang, X Wang… - Nature …, 2022 - nature.com
Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with
obesity are characterized by the excessive plasma kynurenine (Kyn). However, the primary …
obesity are characterized by the excessive plasma kynurenine (Kyn). However, the primary …
[HTML][HTML] Chop deficiency protects mice against bleomycin-induced pulmonary fibrosis by attenuating M2 macrophage production
C/EBP homologous protein (Chop) has been shown to have altered expression in patients
with idiopathic pulmonary fibrosis (IPF), but its exact role in IPF pathoaetiology has not been …
with idiopathic pulmonary fibrosis (IPF), but its exact role in IPF pathoaetiology has not been …
Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity
M Jiang, X Yi, S Hsu, CY Wang… - American Journal of …, 2004 - journals.physiology.org
Tubular damage by cisplatin leads to acute renal failure, which limits its use in cancer therapy.
In tubular cells, a primary target for cisplatin is presumably the genomic DNA. However, …
In tubular cells, a primary target for cisplatin is presumably the genomic DNA. However, …
Obesity predisposes to the risk of higher mortality in young COVID‐19 patients
…, F Wang, G Li, K Liu, R Du, CY Wang… - Journal of medical …, 2020 - Wiley Online Library
Although emerging data demonstrated mortality of young COVID‐19 patients, no data have
reported the risk factors of mortality for these young patients, and whether obesity is a risk for …
reported the risk factors of mortality for these young patients, and whether obesity is a risk for …