The relationship between pharmacokinetics and pharmacodynamic action as applied to in vivo pA2: application to the analgesic effect of morphine.

RJ Tallarida, C Harakal, J Maslow, EB Geller… - … of Pharmacology and …, 1978 - ASPET
When the pA2 of an antagonist is determined in vivo, administered doses are used rather
than the peak or steady-state tissue concentrations. The present report examines the error …

Ketamine directly dilates bovine cerebral arteries by acting as a calcium entry blocker

…, FB Daniels, D Chen, C Harakal… - Journal of …, 1994 - journals.lww.com
This in vitro study was performed to determine the role of calcium in ketamine-induced
cerebral vasodilatation. Isolated bovine middle cerebral arteries were cut into rings to measure …

The effects of N-methyl-D-aspartate agonists and antagonists on isolated bovine cerebral arteries

…, MR Monteforte, MB Fischer, C Harakal… - Anesthesia & …, 1996 - journals.lww.com
This pharmacologic study examines the direct cerebrovascular effects of N-methyl-D-aspartate
(NMDA) receptor agonists and antagonists to determine whether large cerebral arteries …

Effects of prostaglandin F2 alpha and thromboxane A2 analogue on bovine cerebral arterial tone and calcium fluxes.

WW Wendling, C Harakal - Stroke, 1991 - Am Heart Assoc
We determined sources of activator calcium for prostanoid-induced cerebrovascular constriction
by measuring isometric tension and calcium-45 (45Ca) fluxes in bovine middle cerebral …

N-methyl-D-aspartate (NMDA) antagonists—S (+)-ketamine, dextrorphan, and dextromethorphan—act as calcium antagonists on bovine cerebral arteries

…, D Chen, KS Wendling, C Harakal… - Journal of …, 2008 - journals.lww.com
Ketamine, an intravenous anesthetic and a major drug of abuse, is a noncompetitive N-methyl-D-aspartate
(NMDA) receptor antagonist. Ketamine's enantiomer, S (+)-ketamine, acts …

Effects of calcium antagonists on isolated bovine cerebral arteries: inhibition of constriction and calcium-45 uptake induced by potassium or serotonin.

WW Wendling, C Harakal - Stroke, 1987 - Am Heart Assoc
The purpose of this study was to determine the mechanisms by which organic calcium channel
blockers inhibit cerebral vasoconstriction. Isolated bovine middle cerebral arteries were …

Hemodynamic changes in adrenalectomized dogs

…, EA Ohler, RW SEVY, C HARAKAL - …, 1963 - academic.oup.com
Hemodynamic studies were conducted in trained, unanesthetized dogs before and after
complete adrenalectomy. Three days after complete adrenalectomy there were consistent and …

Characteristics of photorelaxation in vascular smooth muscle: Evidence supporting the hypothesis of drug-receptor equilibrium disturbance

RJ Tallarida, RW Sevy, C Harakal… - IEEE Transactions on …, 1975 - ieeexplore.ieee.org
The affinity of norepinephrine for the α-adrenergic receptor in rabbit thoracic aorta is
determined by three different methods. The first method assumes that the effect is directly …

Changes in hypertensinase and hypertensinogen following nephrectomy

DA Collins, CD Harakal - Circulation Research, 1954 - Am Heart Assoc
The hypertensinase content of dog's plasma is decreased 48 hours after nephrectomy. This
decrease may contribute to the increased blood pressure response to renin shown by …

Mediation of bradykinin-induced contraction in canine veins via thromboxane/prostaglandin endoperoxide receptor activation.

MO Aksoy, C Harakal, JB Smith… - British journal of …, 1990 - ncbi.nlm.nih.gov
Canine jugular and femoral veins were studied to determine the possible importance of
thromboxane (TXA2) and prostaglandin endoperoxides (prostaglandin H2, PGH2) in mediating …