ANTIDIURESIS, the recovery of water from the lumen of the renal collecting tubule, is
regulated by the hypothalamic release of antidiuretic hormone (ADH), which binds to specific …

G protein-coupled receptor (GPCR) oligomerization is a growing concept that has emerged
from several studies suggesting that GPCRs can form both homo- and heterodimers. Using …

(2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine
carboxamide (SSR149415), the first …

SR 121463A, a potent and selective, orally active, nonpeptide vasopressin V2 receptor
antagonist, has been characterized in several in vitro and in vivo models. This compound …

To identify receptor functional domains underlying binding of the neurohypophysial
hormones vasopressin (AVP) and oxytocin (OT), we have constructed a three-dimensional (3D) …

Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize
additional nutrient sources to meet their enhanced bioenergetic requirements. Glutamine (…

An oxytocic antagonist, [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid,2-O-methyltyrosine,4-threonine,8-ornithine,
9-tyrosylamide]vasotocin (d(CH 2 ) 5 [Tyr(Me) 2 ,Thr 4 ,Tyr-…

V1a vasopressin receptor (V1aR) and V2 vasopressin receptor (V2R) present distinct
mechanisms of agonist-promoted trafficking. Although both receptors are endocytosed by way of β-…

A cDNA of 2149 base pairs with an incomplete open reading frame (ORF) encoding amino
acids 1–516 of a 531-amino acid protein highly homologous to muscarinic receptors was …

We investigated the mechanisms that regulate the efficacy of agonists in the arginine‐vasopressin
(AVP)/oxytocin (OT) receptor system. In this paper, we present evidence that AVP, a …