γ-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
RD Meng, CC Shelton, YM Li, LX Qin, D Notterman… - Cancer research, 2009 - AACR
Because Notch signaling is implicated in colon cancer tumorigenesis and protects cells
from apoptosis by inducing prosurvival targets, it was hypothesized that inhibition of Notch …
from apoptosis by inducing prosurvival targets, it was hypothesized that inhibition of Notch …
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity
AH Lichtman, D Leung, CC Shelton… - … of Pharmacology and …, 2004 - ASPET
Fatty acid amide hydrolase (FAAH) is the primary catabolic regulator of several bioactive
lipid amides in vivo, including the endogenous cannabinoid anandamide and the sleep-…
lipid amides in vivo, including the endogenous cannabinoid anandamide and the sleep-…
Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia
AH Lichtman, CC Shelton, T Advani, BF Cravatt - Pain, 2004 - Elsevier
Although the N-arachidonoyl ethanolamine (anandamide) binds to cannabinoid receptors
and has been implicated in the suppression of pain, its rapid catabolism in vivo by fatty acid …
and has been implicated in the suppression of pain, its rapid catabolism in vivo by fatty acid …
Dysprosium-doped cadmium oxide as a gateway material for mid-infrared plasmonics
The interest in plasmonic technologies surrounds many emergent optoelectronic applications,
such as plasmon lasers, transistors, sensors and information storage. Although plasmonic …
such as plasmon lasers, transistors, sensors and information storage. Although plasmonic …
Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell
A Schlesinger, CA Shelton, JN Maloof… - Genes & …, 1999 - genesdev.cshlp.org
In a four-cell-stage Caenorhabditis elegans embryo, Wnt signaling polarizes an endoderm
precursor called EMS. The polarization of this cell orients its mitotic spindle in addition to …
precursor called EMS. The polarization of this cell orients its mitotic spindle in addition to …
The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans …
CA Shelton, JC Carter, GC Ellis… - The Journal of cell …, 1999 - rupress.org
Using RNA-mediated genetic interference in a phenotypic screen, we identified a conserved
nonmuscle myosin II regulatory light chain gene in Caenorhabditis elegans, which we …
nonmuscle myosin II regulatory light chain gene in Caenorhabditis elegans, which we …
Activation and intrinsic γ-secretase activity of presenilin 1
K Ahn, CC Shelton, Y Tian, X Zhang… - Proceedings of the …, 2010 - National Acad Sciences
A complex composed of presenilin (PS), nicastrin, PEN-2, and APH-1 is absolutely required
for γ-secretase activity in vivo. Evidence has emerged to suggest a role for PS as the …
for γ-secretase activity in vivo. Evidence has emerged to suggest a role for PS as the …
[PDF][PDF] In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling
…, L Silberstein, G Alexe, MA Al-Hajj, CA Shelton… - Cancer cell, 2013 - cell.com
We used an in vivo small hairpin RNA (shRNA) screening approach to identify genes that
are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) …
are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) …
Hydrogen peroxide generated extracellularly by receptor–ligand interaction facilitates cell signaling
…, O Bórquez-Ojeda, CC Shelton… - Proceedings of the …, 2005 - National Acad Sciences
Reactive oxygen species (ROS) are key components of postreceptor intracellular signaling
pathways; however, the role of ROS in signal initiation is uncertain. We discovered that …
pathways; however, the role of ROS in signal initiation is uncertain. We discovered that …
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
CA Shelton, SA Wasserman - Cell, 1993 - cell.com
The pelle gene is required for the nuclear import of dorsal protein that establishes dorsoventral
polarity in Drosophila embryos. We report here the genetic mapping and molecular …
polarity in Drosophila embryos. We report here the genetic mapping and molecular …