Macitentan, also called Actelion-1 or ACT-064992 [N-[5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)-pyrimidin-4-yl]-N′-propylaminosulfonamide],
is a new dual ET A /ET …

The serum glycoprotein fetuin is expressed during embryogenesis in multiple tissues
including limb buds and has been shown to promote bone remodeling and stimulate cell …

Starting from the structure of bosentan (1), we embarked on a medicinal chemistry program
aiming at the identification of novel potent dual endothelin receptor antagonists with high oral …

Sphingosine-1-phosphate (S1P) is a widespread lysophospholipid which displays a wealth
of biological effects. Extracellular S1P conveys its activity through five specific G-protein …

C-arm cone-beam computed tomography (CT) with a flat-panel detector represents the next
generation of imaging technology available in the interventional radiology suite and is …

There is currently no consensus regarding preferred clinical outcome measures following
image-guided tumor ablation or clear definitions of oncologic end points. This consensus …

Purpose To prospectively compare the diagnostic accuracy of diffusion-weighted whole
body imaging with background whole body signal suppression (DWIBS) with skeletal …

Purpose To prospectively investigate and monitor the response to antiandrogen treatment
of bone metastases in patients with prostate cancer by using diffusion-weighted (DW) …

Osteoporosis is a common problem of aging and results from a failure of homeostatic
mechanisms to regulate osteogenesis and mineralization. Bovine and human forms of fetuin …

PURPOSE: Evaluation of clinical aspects and cost-effectiveness of use of self-expanding
metallic stents in the treatment of acute colonic obstruction as either a preoperative procedure …