Targeting DnaN for tuberculosis therapy using novel griselimycins

…, H Hoffmann, S Klieber, M Kohlmann, M Kurz, C Lair… - Science, 2015 - science.org
The discovery of Streptomyces-produced streptomycin founded the age of tuberculosis therapy.
Despite the subsequent development of a curative regimen for this disease, tuberculosis …

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl) ethyl] 5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride …

…, M Geslin, L Serva, E Fontaine, P Roger, C Lair… - … of Pharmacology and …, 2002 - ASPET
… Danielle Gully, Michel Geslin, Laurence Serva, Evelyne Fontaine, Pierre Roger, Christine
Lair, Valerie Darre, Claudine Marcy, Pierre-Eric Rouby, Jacques Simiand, Josette Guitard, …

Effects of divalent cations and of a calcimimetic on adrenocorticotropic hormone release in pituitary tumor cells

S Ferry, B Chatel, RH Dodd, C Lair, D Gully… - Biochemical and …, 1997 - Elsevier
The calcium sensing receptor (CaSR), a member of the G-protein coupled receptor family, is
expressed on a variety of cell types and responds to extracellular calcium. We have …

Identification and optimization of a new series of anti-tubercular quinazolinones

C Couturier, C Lair, A Pellet, A Upton, T Kaneko… - Bioorganic & Medicinal …, 2016 - Elsevier
A high throughput phenotypic screening against Mycobacterium smegmatis led us to the
discovery of a new class of bacteriostatic, highly hydrophobic antitubercular quinazolinones …

[PDF][PDF] Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents

J Zhang, C Lair, C Roubert, K Amaning, MB Barrio… - Cell, 2023 - cell.com
The emergence of drug-resistant tuberculosis has created an urgent need for new anti-tubercular
agents. Here, we report the discovery of a series of macrolides called sequanamycins …

[HTML][HTML] Pseudomonas aeruginosa manipulates redox and iron homeostasis of its microbiota partner Aspergillus fumigatus via phenazines

B Briard, P Bomme, BE Lechner, GLA Mislin, V Lair… - Scientific reports, 2015 - nature.com
The opportunistic fungal pathogen Aspergillus fumigatus is increasingly found as a
coinfecting agent along with Pseudomonas aeruginosa in cystic fibrosis patients. Amongst the …

A multi-level biological approach to evaluate impacts of a major municipal effluent in wild St. Lawrence River yellow perch (Perca flavescens)

…, P Couture, AO De Silva, C Spencer, S Lair… - Science of the total …, 2014 - Elsevier
The development of integrated ecotoxicological approaches is of great interest in the
investigation of global concerns such as impacts of municipal wastewater effluents on aquatic …

Interrogating trans* identities in the archives

LO Lair - Out of the closet, into the archives: Researching sexual …, 2015 - books.google.com
… Liam Oliver Lair Christine Jorgensen is undoubtedly one of the most famous trans-identified
people in US history. Her story created a media frenzy in 1952 when the New York Daily …

Au pays de Tristan Corbiere

S Lair - 2018 - JSTOR
… Sous l’autorité de la muse Ironie, maîtresse corbiérienne, l’impuissance se décline sous ses
formes amoureuse (de Christine à Herminie, Tristan passe de Charybde en Sylla), picturale …

Aspergillus fumigatus conidia inhibit tumour necrosis factor- or staurosporine-induced apoptosis in epithelial cells

N Berkova, S Lair-Fulleringer, F Féménia… - International …, 2006 - academic.oup.com
A major innate immune response to inhaled conidia of the opportunistic pathogen Aspergillus
fumigatus (Af) is the synthesis of pro-inflammatory cytokines, which include tumour …