Several extracellular agents and stress stimuli, such as tumour necrosis factor α, chemotherapeutic
agents and heat, cause ceramide accumulation. They do this by regulating enzymes …

Many enzymes of sphingolipid metabolism are regulated in response to extra- and intracellular
stimuli and in turn serve as regulators of levels of bioactive lipids (such as sphingosine, …

A high throughput screen for neutral, magnesium-dependent sphingomyelinase (SMase)
was performed. One inhibitor discovered in the screen, GW4869, functioned as a …

Sphingomyelin synthase (SMS), an enzyme involved in sphingomyelin (SM) and ceramide
metabolism, can potentially regulate, in opposite directions, the levels of ceramide and …

In this issue of the JCI, the observation of the altered pathogenicity of a Cryptococcus
neoformans glucosylceramide (GlcCer) mutant shines new light on the initiation of cryptococcal …

The sphingolipids are a class of lipids that serve as integral components of eukaryotic cell
membranes (21, 49). Although previously considered to be simply structural molecules, …

Neutral sphingomyelinase (N-SMase) is one of the key enzymes involved in the generation
of ceramide; however, the gene(s) encoding for the mammalian N-SMase is still not well …

There is an urgent need to identify the cellular and molecular mechanisms responsible for
severe COVID-19 that results in death. We initially performed both untargeted and targeted …

Cryptococcus neoformans is a leading cause of life-threatening fungal infection in
immunocompromised patients. Inositol-phosphoryl ceramide synthase 1 (Ipc1) is a fungus-specific …

Recently, we reported that neutral sphingomyelinase 2 (nSMase2) functions as a bona fide
neutral sphingomyelinase and that overexpression of nSMase2 in MCF7 breast cancer cells …